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Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects multiple body systems, with skin involvement being a common and early symptom. This research explores the role of TREX1 gene mutations and other gene polymorphisms related to SLE, focusing on how these genetic factors influence skin symptoms and disease activity. The study also examines autoantibody profiles and their connection to clinical features in Egyptian patients, aiming to improve early diagnosis and personalized treatments. Participants will undergo diagnostic testing to evaluate selected autoantibodies such as anti-dsDNA, anti-Sm, anti-Ro/SSA, and anti-La/SSB, along with analysis of TREX1 gene polymorphisms. These assessments are designed to understand the prevalence of these markers in SLE patients and how they relate to disease features and activity. The study involves genetic testing and clinical evaluations tied to the participants' cutaneous lupus manifestations. During the study, participants' disease characteristics and activity will be assessed alongside genetic and antibody testing. Researchers will monitor systemic lupus erythematosus assessments and the presence of TREX1 gene polymorphisms over a 3-month period. The goal is to correlate these findings with clinical symptoms to inform better disease management. Participation includes consent for genetic testing and clinical evaluations within the specified age range of 18 to 60 years.

Researchers are evaluating two surgical techniques, bipolar transurethral resection of the prostate (TURP) and bipolar transurethral enucleation of the prostate (TUEP), to treat benign prostatic hyperplasia (BPH) causing lower urinary tract symptoms. The study aims to compare the effectiveness and safety of these procedures, as TURP has been the standard treatment but is associated with significant risks and complications, including long hospital stays and catheterization times. Newer minimally invasive procedures like bipolar enucleation show promise with fewer complications and better recovery profiles. Participants will undergo either TURP, where excess prostate tissue is removed using a bipolar loop diathermy via cystoscopy, or TUEP, which involves anatomically removing the prostate tissue with a bipolar enucleation loop. Both procedures are performed endoscopically. This randomized clinical study compares these two approaches to determine which offers better outcomes for patients requiring surgical intervention for BPH. During the study, participants will be monitored for relief from catheter use and lower urinary tract symptoms for at least six months up to one year following surgery. Researchers will assess symptom improvement, urinary flow rates, and safety outcomes. The study includes men aged 50 to 80 with moderate to severe symptoms and enlarged prostate size. Follow-up evaluations will include clinical assessments and symptom scoring to measure treatment success and monitor any complications.

Psoriasis is a chronic inflammatory skin disease affecting 1-3% of the global population, characterized by scaly, thickened red patches. Psoriatic arthritis (PsA) is an autoimmune disorder linked to psoriasis, causing joint pain, stiffness, and swelling, with symptoms ranging from mild to severe. This research investigates the relationship between the Card14 gene polymorphism and the clinical response to methotrexate treatment in Egyptian patients with psoriasis and psoriatic arthritis, aiming to better understand disease mechanisms and treatment effects. The study evaluates the use of methotrexate, a longstanding treatment for moderate to severe psoriasis and psoriatic arthritis, comparing its effects against a placebo. Methotrexate's role includes managing skin and joint symptoms, with the study also assessing how gene variations might influence treatment response. Participants will receive either methotrexate or placebo, and their disease severity and response will be monitored throughout the study. Participants will undergo clinical assessments including the Psoriasis Area and Severity Index (PASI) to measure disease extent and severity. Researchers will monitor treatment response over three months, focusing on skin and joint improvements. Safety monitoring will address potential adverse effects, and data on genetic markers will be collected to correlate with treatment outcomes. The total study participation spans at least three months to evaluate methotrexate's effectiveness and genetic influences on psoriatic disease.

Researchers are comparing a home vision self-assessment test to the traditional office-based Snellen visual acuity test in children with myopia. Visual impairment affects over 400 million people worldwide and poses a significant public health and socioeconomic challenge. Home vision tests provide a way to measure visual acuity without needing to visit a clinic, which can help doctors monitor vision remotely, especially after treatments or during follow-up telemedicine visits. The study involves children using a home vision test where they perform the assessment at a 5 feet distance while wearing their current corrective lenses. Each eye is tested separately in a well-lit area. In the office, trained technicians perform the Snellen chart test under standardized conditions with dimmed lighting and an illuminated screen; patients also wear their corrective lenses and cover one eye at a time. The test measures visual acuity from 20/16 to 20/200. Participants will complete both the home and office vision tests, allowing researchers to compare the agreement between the two methods immediately after testing. The study includes assessments of visual acuity and ensures safety by excluding children with severe eye conditions or systemic diseases. The total involvement depends on test completion and follow-up visits for the office-based assessments.

Researchers are comparing the effects of dry cupping massage and myofascial release therapy in adults aged 18 to 40 who have mechanical neck pain lasting at least three months. Mechanical neck pain is common and impacts daily life and work productivity, but there is no single definitive treatment. This study explores whether these two non-pharmacological therapies differ in their impact on pain, neck movement, and functional ability. Participants will receive either dry cupping massage, which uses suction cups with circular and transverse movements without injuring the skin, or myofascial release, a hands-on manual therapy aimed at improving tissue flexibility and elasticity. Treatment sessions will be conducted three times per week for four weeks, totaling 12 sessions. Before and after each treatment session, researchers will assess the participants' neck range of motion to measure changes. Other evaluations will include pain level and functional status related to neck pain. This study is designed to determine if there is a meaningful difference between these two therapies in improving symptoms of mechanical neck pain.

Psoriasis is a chronic inflammatory skin disorder characterized by red, scaly plaques commonly found on the extensor surfaces, scalp, and lower back. It can also affect the eyes and joints, leading to psoriatic arthritis in 20-30% of patients. The disease impacts quality of life and is linked to increased risk of depression and cardiovascular problems. This research investigates the role of a genetic variation, IL 12B polymorphism (rs3213094), in patients with psoriasis and psoriatic arthritis and how it relates to treatment response. The study evaluates the response to Humira (adalimumab), a medication that targets tumor necrosis factor-alpha (TNF-α) to reduce inflammation in moderate-to-severe psoriasis and psoriatic arthritis. Participants with severe psoriasis and psoriatic arthritis will receive Humira. The study also analyzes the genetic association between the IL 12B polymorphism and treatment outcomes. This treatment is given during the study period, and the effects on skin and joint symptoms are monitored. Participants will be assessed for disease severity using the Psoriasis Area and Severity Index (PASI) and body surface area involvement. Researchers will monitor treatment response over three months, focusing on improvements in psoriasis and psoriatic arthritis symptoms. Safety and effectiveness of Humira will be evaluated, along with genetic testing for the IL 12B polymorphism. The total duration of participation involves initial diagnosis confirmation and a 3-month treatment and observation period.

Postoperative pain after hip fracture surgery can be severe, especially when moving, which may affect recovery. Researchers are studying a new technique called the femoral rami obturator nerve trunk (FRONT) block to improve pain relief after intramedullary nail surgery for hip fractures. This technique aims to provide better coverage of the nerves supplying the front of the hip joint, potentially enhancing early recovery and outcomes. The FRONT block is performed before surgery using ultrasound and electrical nerve stimulation guidance to target two nerve areas through a single needle entry. A local anesthetic called levobupivacaine is injected in two specific areas, while avoiding motor nerves to help preserve movement. All patients also receive standard postoperative pain medications including nalbuphine, paracetamol, and ketorolac as needed. Participants will be followed for 36 hours after surgery to monitor their pain levels at multiple time points. Researchers will assess how well the FRONT block provides pain control during this period. This includes evaluating pain scores at 2, 4, 6, 12, 18, 24, and 36 hours after the spinal anesthesia. The study focuses on elderly patients undergoing this type of hip surgery and aims to improve postoperative pain management and recovery.

Psoriasis is a common immune-related inflammatory disease affecting 2-3% of people worldwide, marked by red, scaly patches on the skin that cause physical and emotional challenges. Psoriatic arthritis (PsA) is a chronic inflammatory arthritis linked to psoriasis, involving joints and the spine, and develops in up to 30% of psoriasis patients. The study focuses on the genetic variation in the TRAF3IP2 gene, which plays a role in immune system regulation and inflammation, to understand its association with psoriasis, psoriatic arthritis, and treatment outcomes with Methotrexate. The study evaluates Methotrexate, a longstanding treatment for moderate to severe psoriasis and psoriatic arthritis, known for its effectiveness and affordability. Participants will receive Methotrexate therapy, and researchers will assess the drug's impact on skin and joint symptoms over three months. They will also explore how genetic differences in TRAF3IP2 affect treatment response. The study involves careful monitoring of participants starting Methotrexate treatment and includes follow-up visits to track progress. Participants will undergo clinical evaluations including severity scoring of skin symptoms and confirmation of psoriatic arthritis diagnosis by specialists. The study collects data on treatment effects and genetic markers to better understand disease mechanisms and therapy response. Follow-up visits ensure ongoing assessment of safety and effectiveness over the three-month period, helping researchers evaluate Methotrexate's role in managing psoriasis and psoriatic arthritis.

Genitovesical fistula is an abnormal connection between female reproductive organs and the lower urinary tract, such as the bladder and urethra. This condition can severely affect women's physical and psychological health, lowering their quality of life. Causes differ by region: in developed countries, it often results from surgical injury, while in developing countries, it is usually due to complicated labor. The study compares laparoscopic repair with open surgical repair of genitovesical fistulas in females. Laparoscopy is a minimally invasive procedure that may offer benefits like less pain, smaller incisions, reduced blood loss, shorter hospital stays, and faster recovery compared to open surgery. Treatment timing is planned 2 to 6 months after symptom onset. Participants will be monitored from baseline to 2 months after surgery to evaluate treatment success. Assessments include clinical evaluations and follow-up to measure fistula healing and symptom resolution. Researchers will track outcomes related to fistula repair effectiveness and safety during this period.

Varicocele is an abnormal enlargement or twisting of veins in the scrotum, commonly affecting the left side but sometimes both sides. It can negatively impact sperm production, testicular size, semen quality, and fertility outcomes. This research investigates treatments for men with varicocele-related infertility and isolated teratozoospermia, focusing on comparing medical, surgical, and combined approaches. The study compares three treatment options: medical treatment using l-carnitine and antioxidants, surgical treatment through varicocelectomy, and a combination of surgery plus medical treatment. Varicocelectomy is considered the standard surgical option with high success and low complications. Medical management with antioxidants aims to reduce oxidative damage linked to infertility. Diagnosis is based on physical examination by a trained physician. Participants will be monitored to evaluate the number of men successfully treated for teratozoospermia after three months. Researchers will assess semen parameters and fertility-related outcomes. The study focuses on men aged 20 to 50 with palpable varicoceles and isolated teratozoospermia, tracking treatment effects and safety throughout the study period.