Zagazig 2

Researchers are evaluating the long-term safety and effects of etavopivat, a new oral medicine being developed for inherited blood disorders such as sickle cell disease and thalassaemia. These conditions affect haemoglobin, the protein responsible for carrying oxygen in the blood. This phase 3 study involves participants who have already completed treatment in a prior etavopivat study and aims to understand how etavopivat performs over an extended period of up to 264 weeks, though the study may end earlier if the drug gains approval locally. Participants will receive oral doses of etavopivat, with different forms A, B, or C given based on their age and condition. Those aged 12 years and older will receive etavopivat A or C, while children under 12 years will receive etavopivat B. The study includes several groups covering various sickle cell disease and thalassaemia categories, including transfusion-dependent and non-transfusion-dependent cases. Treatment is continuous during the study period. Throughout the study, participants will undergo regular monitoring for side effects and treatment responses, including tracking treatment emergent adverse events, hospitalizations, vaso-occlusive crises, hemoglobin concentration changes, and blood transfusion needs. These assessments will help evaluate the drugs safety and efficacy across age groups and disease types. The study is open-label and non-randomized, with follow-up lasting up to about six years.

Researchers are studying the use of an infraspinatus-teres minor ITM block to improve pain relief before shoulder surgeries. The study aims to see if this block reduces opioid use, enhances overall analgesia, and affects other factors like pain scores, discharge time, and side effects compared to standard general anesthesia. This is a randomized controlled study sponsored by Zagazig University focusing on patients aged 21 to 65 undergoing unilateral shoulder surgery. Participants will be randomly assigned to one of two groups. One group will receive an ultrasound-guided ITM block with local anesthetics including bupivacaine, dexmedetomidine, and dexamethasone before general anesthesia. The other group will receive general anesthesia without the block. The surgery duration is expected to be less than 3 hours, and treatments are administered before surgery. During the study, participants will be monitored for pain using a numerical rating scale at rest and during shoulder movement at several time points up to 24 hours after surgery. Researchers will track opioid consumption, time until first rescue analgesic use, discharge time from the post-anesthesia care unit, side effects of opioids, block-related complications, and patient satisfaction with analgesia. The total participation includes the surgery and 24 hours of postoperative observation.

Researchers are evaluating two different ultrasound-guided nerve block techniques to manage pain in patients undergoing total hip arthroplasty THA, a common surgery for hip fractures and osteoarthritis. The study compares the anterior iliopsoas muscle space block and the supra-iliac anterior quadratus lumborum block as pre-emptive analgesia during general anesthesia. Effective pain control is crucial to improve recovery, reduce hospital stay, and support early mobilization after surgery. Participants will be randomly assigned to one of three groups a control group receiving general anesthesia alone, a group receiving the anterior iliopsoas muscle space block with 30 ml of bupivacaine 0.25% before general anesthesia, or a group receiving the supra-iliac anterior quadratus lumborum block with the same anesthetic dosage before general anesthesia. These blocks target nerves around the hip joint to reduce postoperative pain. During the study, researchers will assess pain using the Visual Analogue Scale at multiple times up to 24 hours after surgery and measure the total rescue analgesia used in the first 24 hours. Patients will be monitored closely for outcomes related to pain relief and recovery. The study is sponsored by Zagazig University and aims to identify the most effective regional anesthesia technique for THA patients aged 50 to 80 years.

Researchers are studying the safety and effectiveness of Candida antigen and bivalent HPV vaccine in treating common warts. The trial compares these treatments given alone or combined to see how well they clear warts and prevent recurrence. This is a Phase 2 randomized study involving patients with multiple warts. Participants are divided into three groups one receives Candida antigen injections directly into the largest wart, another receives bivalent HPV vaccine injections, and the third group receives both treatments together. Injections are given every two weeks for up to five sessions or until the warts clear. During the study, patients will be monitored for complete, partial, or no response to treatment over three months. Researchers will also follow up for six months after recovery to check for wart recurrence. Assessments include clinical evaluation of warts and treatment safety throughout the trial.

Hip fractures are a significant global health issue for older adults, with high mortality rates and serious impacts on independence and quality of life. Surgical treatment is the preferred option for hip fractures in the elderly, but it often causes moderate to severe pain after surgery. Effective pain management and early rehabilitation are crucial for recovery, reducing hospital stay, and improving mobility. This trial explores new approaches to pain relief after hip fracture surgery, comparing two nerve block techniques to find better pain control methods under general anesthesia. The study compares ultrasound-guided circum-psoas block and combined lumbar and sacral plexus blocks as methods of pain relief after hip fracture surgery. Participants will receive general anesthesia and then one of the two nerve block techniques using 40 ml of 0.25% bupivacaine. The lumbar and sacral plexus blocks aim to block nerves supplying the hip, while the circum-psoas block targets key lumbar plexus branches. The comparison evaluates which approach provides better sensory block and postoperative pain relief. Participants will be monitored for pain levels using the Visual Analogue Scale at several time points up to 24 hours after surgery. Sensory block levels will be assessed at 2 hours postoperatively, and the total dose of additional pain medication needed in the first 24 hours will be recorded. The study uses randomized, double-blind methods to compare these techniques in patients aged 60 and older undergoing hip fracture surgery. The trial will help determine effective pain management strategies for this patient group.

Researchers are evaluating the clinical performance of two supraglottic airway devices, Laryseal Clear and Ambu Aura40 laryngeal masks, in preschool children undergoing surgery. The study focuses on children aged 3 to 6 years and aims to compare the effectiveness and safety of these devices, which are used to maintain the airway during anesthesia and may cause less stress and fewer complications than traditional methods. This research is conducted at Zagazig University hospitals in their anesthesia and intensive care departments. The study involves randomly assigning children into two groups one group uses the LarySeal Clear device while the other uses the Ambu Aura40 device. Both devices are sized according to the childs weight and inserted following manufacturer guidelines, with differences in head positioning and insertion technique. Anesthesia is induced with sevoflurane and intravenous medications, and the devices are inserted after ensuring proper anesthesia depth. Device placement is confirmed by monitoring oxygen levels, chest movement, and ventilation, with up to three attempts allowed before switching to an endotracheal tube if needed. During the study, children will be closely monitored with standard anesthesia equipment and assessed for airway device performance, including leak pressure measurements and ease of insertion. Researchers will also observe and record any complications during and after surgery, such as coughing, airway obstruction, or trauma. Follow-up includes evaluation in the post-anesthesia care unit and up to 24 hours after the procedure to check for any related side effects. Participation lasts through the surgical procedure and immediate recovery period, with safety and device effectiveness as primary outcomes.

Alopecia areata AA is an autoimmune condition causing non-scarring hair loss in round or oval patches, often affecting the scalp, beard, eyebrows, and eyelashes. This trial studies the effects of combining microneedling with either 1% lactic acid solution, vitamin D3, triamcinolone acetonide, or saline to evaluate hair regrowth in patients with localized patchy AA. The study aims to better understand these treatments potential in promoting hair growth by modulating immune responses and stimulating hair follicles. Participants will be divided into four groups, each receiving microneedling with a different topical agent lactic acid 1%, vitamin D3 solution, triamcinolone acetonide injectable suspension, or normal saline. Microneedling sessions will be performed every two weeks for up to six sessions, using a dermapen device with a needle length of 1.5 to 2 mm. Topical anesthetic cream is applied before treatment, and microneedling continues until pinpoint bleeding occurs. During the study, photographs will be taken before, during, and after treatment to monitor progress. The main outcome measured is hair regrowth improvement assessed by the Severity of Alopecia Tool SALT score and percentage of hair growth over three months. Participants will be evaluated regularly, with attention to treatment response and safety, under the supervision of study staff until study completion in late 2026.

This research aims to develop and validate a machine learning model that combines chest X-ray results with arterial blood gas ABG analysis to predict the need for mechanical ventilation in critically ill adult patients. The study is conducted at Zagazig University Hospitals and seeks to improve critical care decisions by integrating radiological and biochemical data using artificial intelligence, comparing the models predictions against standard clinical assessments. The study plans to enroll about 2,160 critically ill adults over six months. Participants include those clinically assessed to require mechanical ventilation and a control group of age- and sex-matched critically ill patients who do not need ventilation. Data collected include chest X-ray findings and ABG parameters such as pH, PaO2, PaCO2, and HCO3. The machine learning model will be trained on 70% of the data and tested on the remaining 30%, with performance measured by accuracy and error metrics. Participants will undergo evaluation including chest X-rays and ABG tests at the time of assessment. Researchers will collect demographic and clinical information to support model development. The study measures the models accuracy in predicting ventilation needs within 24 hours of patient presentation. Ethical approval has been obtained, and the study is designed to enhance objective and efficient management of critically ill patients using combined imaging and laboratory data.

The trial investigates the use of ultrasound-guided regional anesthesia compared to traditional general anesthesia for patients undergoing tympanoplasty surgery. It aims to evaluate how well ultrasound-guided nerve blocks work during awake surgery and their effects on recovery and surgical outcomes. The study focuses on patients aged 21 to 65 years who are scheduled for elective unilateral tympanoplasty and have certain physical health statuses. Participants will be randomly assigned to one of two groups. One group receives regional anesthesia where specific nerves around the ear are numbed using ultrasound to guide precise needle placement. The other group will receive general anesthesia as is traditionally done. The study will measure factors like the time patients take to be discharged from the recovery unit, the quality of the surgical field, and how successful the nerve block is. Both groups will be monitored for any anesthesia or surgery-related complications. Throughout the study, researchers will closely assess participants vital signs, pain levels, opioid use, and satisfaction of both patients and surgeons. Measurements include blood pressure and heart rate during surgery, pain ratings at multiple points up to 24 hours after surgery, and the time until patients first request pain relief. Safety and effectiveness data will also be collected, including any block failures or side effects. The overall participation duration includes the surgery and a 24-hour postoperative period for observation and evaluation.

Researchers are studying adults aged 45 to 80 with knee osteoarthritis that has not improved with standard treatments. The study compares two methods of genicular nerve ablation, guided by CT imaging or fluoroscopy, to see which better reduces knee pain and improves function. The trial also looks at safety and patient satisfaction with each technique. Participants receive either CT-guided or fluoroscopic-guided genicular nerve ablation. The CT-guided method uses detailed CT scans to precisely place needles near the nerves causing pain, while the fluoroscopic method uses real-time X-ray images to guide needle placement. Both procedures aim to disrupt pain signals from the knee nerves. The study standardizes treatment settings and carefully monitors all participants. Participants will have follow-up visits at 1 week, 1 month, 3 months, and 6 months after the procedure. During these visits, researchers will assess pain levels using the visual analog scale, evaluate knee function with a specialized arthritis score, and record any side effects or issues. Patient satisfaction is also measured through questionnaires. The main focus is on pain reduction at 3 months, with ongoing monitoring through 6 months.