Kirikkale Merkez

Researchers are evaluating erectile function changes in male patients who undergo percutaneous coronary intervention PCI for either a heart attack or stable angina. The study aims to understand how myocardial infarction affects erectile function over time and to explore whether erectile dysfunction can predict future cardiac events. This observational study compares erectile function between patients with myocardial infarction and those with stable angina using standardized questionnaires. Participants are grouped into two sets those treated with PCI after a heart attack and those treated due to stable angina. Erectile function is assessed at baseline after recovery from PCI, and at 3 and 6 months post-procedure using the International Index of Erectile Function IIEF questionnaire. Additional assessments include the Beck Depression Inventory and Fear of Cardiac Recurrence and Progression Scale. Researchers also collect clinical data such as cardiac vessel scores, ejection fraction, testosterone levels, body measurements, medication use, and the intervention method. During the study, male participants aged 30 to 75 will complete face-to-face interviews and questionnaires at specified intervals baseline, 3 months, and 6 months after PCI. The study measures changes in erectile function scores over time and examines associations with cardiac health, depression, and anxiety symptoms. Safety and participation are monitored throughout the follow-up period. The total duration of involvement is up to 6 months, with evaluations focusing on erectile function and related health parameters.

Researchers are evaluating the effectiveness and safety of a combination inhaler containing fluticasone propionate and albuterol sulfate, delivered via a multidose dry powder inhaler with an electronic module, in participants aged 12 years and older with asthma. This Phase 3 trial aims to compare this combination treatment to fluticasone propionate alone, albuterol sulfate alone, or a placebo inhaler. The study also assesses different dosing schedules, safety, tolerability, and pharmacokinetics of these inhalers. Participants will be randomly assigned to one of four groups receiving either the combination inhaler, fluticasone propionate inhaler, albuterol sulfate inhaler, or placebo, all with integrated electronic modules. Treatments are administered over a 4-week period with dosing four times daily. Pharmacokinetic assessments will be conducted after a single dose administration. The study is double-blind and placebo-controlled, with a parallel group design. Throughout the approximately 10-week study period, including screening and treatment, participants will undergo evaluations including lung function tests measuring forced expiratory volume in one second FEV1, asthma control questionnaires, and safety assessments. Researchers will monitor treatment-emergent adverse events and measure blood concentrations of the inhaled drugs. The study includes electronic monitoring of inhaler use and collects data at baseline, during treatment, and at week 4, with follow-up to assess efficacy and safety.

This research aims to evaluate the long-term safety and explore the efficacy of astegolimab in adults aged 40 to 90 years with chronic obstructive pulmonary disease COPD. It focuses on participants who have completed a 52-week placebo-controlled treatment period in previous studies GB43311 or GB44332. The study is a phase 3, open-label extension to gather extended safety information on this drug in COPD patients. Participants from the parent studies who qualify will receive subcutaneous injections of astegolimab every two weeks throughout the study until it ends. This open-label extension allows all participants to receive the active drug without placebo comparison. The study continues treatment beyond the initial 52-week period to monitor long-term effects. During the study, participants will be monitored for adverse events up to 12 weeks after their last dose of astegolimab. Researchers will collect safety data to understand the incidence of any side effects. The study involves regular assessments and follow-ups to ensure participant well-being, with the total duration lasting until July 2034.

Researchers are evaluating the immediate effects of local vibration therapy on walking and balance in adults who have experienced a stroke. The study focuses on how this therapy influences spatiotemporal gait parameters and balance, aiming to explore a treatment method that could support stroke rehabilitation. Local vibration is a mechanical stimulus applied to muscles or tendons and has shown promise in improving motor function and brain reorganization in previous studies, though its impact on the gastrocnemius muscle in stroke patients has not been studied before. Participants will be divided into two groups one receiving local vibration therapy using the Vibrasens device applied to the spastic medial gastrocnemius muscle for 10 minutes at 80Hz frequency and 1 mm amplitude, and the other receiving a placebo application to the same area for 10 minutes. This randomized study compares the effects of actual vibration treatment with placebo to assess differences in gait and balance. During the study, participants will undergo multiple assessments including the Modified Ashworth Scale, Timed Up and Go Test, Functional Reaching Test, Biodex Computerized Balance System, Tandem Stance, 10 Meter Walking Test, and gait analysis. Each assessment ranges from 5 to 10 minutes, measuring muscle spasticity, balance, walking ability, and functional mobility. The total involvement spans from initial treatment through these evaluations to determine the acute impact of the intervention on stroke recovery.

Researchers are investigating temporomandibular joint TMJ dysfunction, cervical posture, balance, dual-task abilities, and social adaptation skills in children and young adults with autism spectrum disorder ASD. This observational study compares individuals with ASD to those with typical motor development to understand how these factors relate and differ between the groups. The study addresses gaps in understanding the relationship between TMJ problems, posture, balance, and social skills in autism. Participants will undergo several assessments including the Timed Up and Go TUG test for functional balance, the 10-Meter Walk Test with added dual motor and cognitive tasks to evaluate multitasking abilities, the Vineland Adaptive Behavior Scales for social adaptation, and the Helkimo Clinical Dysfunction Index for TMJ dysfunction. Cervical posture will be assessed using a posture analysis app that captures photos to evaluate postural deviations. Both groups will receive the same evaluations. During the study, participants demographic data such as age, height, weight, and habits will be recorded. The assessments will measure balance, posture, TMJ function, dual-task performance, and social skills. These results will be compared between the ASD group and the control group with typical development. The total participation occurs at enrollment, with all evaluations conducted at that time to analyze the relationships among the measured factors.

This research aims to study changes in depressive symptoms and personal esthetic perception in adults with different types of malocclusion who undergo bimaxillary orthognathic surgery. It focuses on understanding the psychological effects and esthetic outcomes of the surgery by analyzing clinical data and patient questionnaires collected before and after the procedure. The study involves adult patients between 18 and 40 years old who are scheduled for this surgery at Krkkale University. Participants will be grouped based on their malocclusion type Skeletal Class I, Class II, or Class III. All participants will undergo bimaxillary orthognathic surgery, and changes in depressive symptoms, self-esteem, esthetic perception, and quality of life related to the surgery will be assessed. The study uses anonymized clinical records and validated questionnaires to collect data at two key points one week before surgery and six months after surgery. During the study, participants will complete assessments about their esthetic perception, depressive symptoms, self-esteem, and quality of life. Researchers will also collect information on demographics and social media use. The primary outcomes measured include changes in depressive symptoms, quality of life, and self-esteem between the preoperative and six-month postoperative visits. The total participation duration covers these two assessment points, supporting a better understanding of psychological and esthetic impacts of orthognathic surgery.

This research aims to compare two types of non-invasive ventilation support devices used during deep sedation for impacted molar tooth extraction in adults aged 18 to 60 years. The study focuses on patients scheduled for surgical tooth extraction lasting between 20 and 60 minutes, examining how these devices affect anesthesia quality, intraoperative and postoperative complications, and satisfaction of both patients and surgeons. The investigation addresses the specific risks and challenges of sedation in dental procedures, especially respiratory complications like hypoxia and respiratory depression, which may be improved by proper ventilation support. Participants receive deep sedation induced with intravenous medications midazolam, propofol, and fentanyl, followed by maintenance using inhaled sevoflurane. They will be randomly assigned to receive ventilation support either through a nasal airway device or a nasal CPAP mask during the procedure. Both groups receive similar sedation protocols, and postoperative analgesia is provided by intravenous paracetamol and dexketoprofen trometamol. The study is conducted at two dental faculties with a total of 60 patients divided equally between the two device groups. Throughout the procedure and for four hours afterward, researchers monitor vital signs including blood pressure, heart rate, oxygen levels, respiratory rate, and ventilation parameters such as tidal volume and end tidal CO2. Postoperative follow-up evaluates complications related to the ventilation devices, including nasal and throat symptoms, as well as patient and surgeon satisfaction scores. Sedation medication doses and recovery time until discharge are also recorded, providing comprehensive data on the safety and comfort of the ventilation methods used during deep sedation.

Researchers are evaluating the effects of different inspiratory to expiratory IE ratios during mechanical ventilation in children aged 2 to 12 years undergoing dental procedures under general anesthesia. This observational study compares the routine IE ratio of 12 with a 13 ratio, aiming to see how these settings affect respiratory function and recovery quality during emergence from anesthesia. The goal is to find the best ventilation strategy to improve safety and comfort for pediatric patients during this process. All participants will receive standard anesthesia and dental care without any additional interventions. The study groups include children who emerge from anesthesia earlier than planned without preparation, those ventilated with an IE ratio of 12, and those ventilated with an IE ratio of 13 during the last phase of the procedure. The IE ratio is adjusted 20-30 minutes before the end of surgery to help transition to spontaneous breathing. Throughout the study, vital signs and respiratory parameters such as heart rate, blood pressure, oxygen saturation, carbon dioxide levels, respiratory rate, and airway pressure will be monitored. Researchers will assess respiratory quality after extubation using a non-invasive scoring system and track recovery outcomes including physical responses, airway complications, anxiety, delirium levels, and discharge times. All data are recorded without altering routine clinical care, and the total follow-up covers emergence and recovery periods.

Researchers are evaluating different non-surgical treatments for peri-implantitis, a condition affecting the tissues around dental implants. This study compares the effectiveness of mechanical debridement, ErYAG laser treatment, and diode laser treatment in reducing the depth of peri-implant sulcus, which is an important measure for this condition. The study sponsor is Kubilay Bar. Participants will be divided randomly into groups a healthy control group with no intervention, a group receiving mechanical debridement once, a group receiving ErYAG laser decontamination three times, and a group receiving diode laser decontamination three times. These treatments aim to address inflammation and bone loss around the implants. During the study, participants will be monitored for changes in probing depth and clinical attachment loss after six months. Additional measures include gingival index, plaque index, and sulcus bleeding index to assess gum health. The study runs from November 2024 to May 2025 and involves regular assessments to track treatment effects and safety.

Researchers are evaluating motor skills, balance, dual task abilities, and social adaptation in individuals with autism spectrum disorder compared to those with normal motor development. The study aims to assess these areas using various tests to better understand differences in motor and social functioning between these groups. This observational study will include participants aged 4 to 21 years and will be conducted after ethics committee approval at a special education and rehabilitation center. Participants will be divided into two groups those with autism spectrum disorder and those with typical motor development. Both groups will undergo the same assessments, including the 10 meter walk test with added dual tasks, the Timed Up and Go TUG test for functional balance, the Vineland Adaptive Behavior Scales for social adaptation, and the Bruininks-Oseretsky Motor Proficiency Test BOT-2 to measure fine motor skills, coordination, strength, and agility. These tests evaluate motor and cognitive tasks, daily living functioning, and motor proficiency across multiple domains. During the study, participants will provide socio-demographic information such as age, height, weight, body mass index, education level, and habits like exercise and smoking. The research team will measure motor skills, functional balance, dual task performance, and social adaptation at enrollment. The primary outcome includes the 10 meter walk test, while secondary outcomes cover functional balance, social adaptation, and motor proficiency. This study will help compare abilities between individuals with autism and those with typical development.