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Researchers are evaluating erectile function changes in men who have undergone percutaneous coronary intervention (PCI) due to either a heart attack or stable angina. The study aims to understand the long-term effect of myocardial infarction on erectile function and to investigate whether erectile dysfunction can predict future cardiac events. This prospective comparative study also looks at various factors influencing erectile status after PCI, including cardiac vessel conditions and medical measurements. Male patients who have successfully undergone PCI are categorized into two groups based on their diagnosis: those with acute myocardial infarction and those with stable angina. The study involves follow-up assessments at baseline (post-recovery), 3 months, and 6 months after PCI. During these visits, participants complete several questionnaires, including the International Index of Erectile Function (IIEF), Beck Depression Inventory, and Fear of Cardiac Recurrence and Progression Scale. Clinical evaluations include cardiac function scores, laboratory tests such as testosterone levels, and measurements of body mass index and waist circumference. Participants will be regularly monitored through face-to-face interviews by trained medical staff during the follow-up visits. The study measures changes in erectile function scores from baseline to 6 months post-PCI. Additional data on medications, medical conditions, and procedural details are also collected to provide a comprehensive understanding of erectile function changes. The total study duration for each participant is 6 months following the PCI procedure.

Researchers are studying the effectiveness and safety of a combination inhaler containing fluticasone propionate and albuterol sulfate delivered through a multidose dry powder inhaler with an electronic module (Fp/ABS eMDPI). This Phase 3 trial focuses on people aged 12 years and older who have asthma. The study also looks at the safety and tolerability of this inhaler when used four times daily over four weeks, as well as the pharmacokinetics of the combination and its individual components after a single dose. Participants will be randomly assigned to receive either the Fp/ABS combination inhaler, fluticasone propionate alone, albuterol sulfate alone, or a placebo inhaler. All treatments are given as inhalation powders. The main treatment period lasts four weeks, during which the inhalers are taken four times a day. The total study duration for each participant is about 10 weeks, not counting an optional prescreening visit. Throughout the study, researchers will measure lung function changes, specifically forced expiratory volume in one second (FEV1), from baseline to week 4. Participants will undergo assessments including lung function tests and safety evaluations. The study monitors how the inhaler affects breathing over time and checks for any side effects or tolerability issues during the treatment period.

Researchers are evaluating the safety and effectiveness of astegolimab compared to a placebo in adults aged 40 to 80 years who have chronic obstructive pulmonary disease (COPD). The study focuses on participants who are former or current smokers with a history of frequent COPD flare-ups. This phase III trial aims to determine how well astegolimab reduces moderate and severe COPD exacerbations over one year. Participants will be randomly assigned to receive either subcutaneous astegolimab every two or four weeks or a placebo every two weeks. All participants will continue their optimized COPD maintenance treatments, which may include combinations of inhaled corticosteroids, long-acting beta-agonists, and long-acting muscarinic antagonists. Study treatments will be administered over a 52-week period. Throughout the study, researchers will monitor the annual rate of moderate and severe COPD exacerbations. Participants will undergo lung function tests, chest imaging, and assessments of breathlessness and lung health. The study will also carefully track the safety of the treatments, including any infections or heart-related problems. The total participation time is 52 weeks, during which the effectiveness and safety of astegolimab will be evaluated.

This research aims to evaluate the long-term safety and explore the effectiveness of astegolimab in people with chronic obstructive pulmonary disease (COPD) who have already completed a 52-week treatment in previous studies GB43311 or GB44332. The study focuses on participants aged 40 to 90 years and is a Phase III open-label extension trial designed to continue monitoring patients after their initial treatment period. Participants will receive astegolimab as a subcutaneous injection every two weeks during this extension study. This treatment continues from the prior placebo-controlled phase, allowing researchers to observe any ongoing effects and safety concerns over a longer period. The study does not include a placebo group during this extension phase, and all participants receive the active treatment. Throughout the study, researchers will closely monitor participants for any adverse events up to 12 weeks after the last dose of astegolimab. Participants will be assessed regularly to ensure their safety and to gather data on the treatment's long-term impact. The total duration of participant involvement depends on when they completed the parent studies but involves continued monitoring during and after the treatment period.

Researchers are investigating the immediate effects of applying local vibration to improve walking and balance in stroke patients aged 45 to 75 years. The study focuses on understanding how vibration therapy influences the timing and spatial aspects of gait, as well as balance, in individuals who have experienced either ischemic or hemorrhagic stroke. This approach is part of a broader effort to explore new rehabilitation methods beyond traditional therapies, including robotic devices and virtual reality, with local vibration showing promise in stimulating motor recovery. Participants in the treatment group will receive local vibration therapy using the Vibrasens9 device, which delivers mechanical vibrations to the medial gastrocnemius muscle for 10 minutes. The vibration is applied at a frequency of 80 Hz with an amplitude of 1 mm. This device is non-invasive and designed specifically for sensory-motor rehabilitation. The study compares the effects of this vibration application on gait and balance parameters to evaluate its potential benefits. During the study, participants will undergo several assessments including the Modified Ashworth Scale, Timed Up and Go Test, Functional Reaching Test, Biodex Computerized Balance System, Tandem Stance, 10 Meter Walking Test, and Gait Analysis. These tests measure muscle spasticity, mobility, balance, and walking ability, each lasting between 5 to 10 minutes. The researchers will use these outcomes to monitor changes in gait and balance following the vibration treatment, ensuring safety and effectiveness throughout the study period.

Researchers are evaluating temporomandibular joint (TMJ) dysfunction, cervical posture, balance, dual-task performance, and social adaptation skills in individuals with autism spectrum disorder (ASD). This study compares these factors between individuals with ASD and those with typical motor development, who serve as a control group. The study addresses gaps in current knowledge, especially regarding dual-task abilities and their impact on social life, as well as the relationship between teeth grinding, TMJ issues, cervical posture, and balance in people with ASD. Participants will be assessed through several tests and tools. TMJ function will be measured using the Helkimo Clinical Dysfunction Index. Cervical posture will be evaluated with an Android-based PostureScreen application and observational analysis. Functional balance will be assessed using the Timed Up and Go (TUG) test, while dual-task abilities will be examined by adding motor and cognitive tasks to the 10-Meter Walk Test. Social adaptation will be evaluated through parent interviews using the Vineland Adaptive Behavior Scales. Participants' socio-demographic information, including age, height, weight, education level, exercise, and smoking habits, will be collected. The study involves taking photos for posture assessment and recording times for walking and balance tests. Researchers will analyze relationships between TMJ, cervical posture, balance, dual-task skills, and social adaptation in individuals with autism compared to controls. The primary outcome measured at enrollment is cervical posture assessment. The study includes individuals aged 4 to 21 years with ASD and typical motor development controls.

Researchers are comparing two types of non-invasive ventilation support during deep sedation in patients undergoing impacted molar tooth extraction. The study focuses on evaluating anesthesia quality, postoperative complications, and satisfaction levels in adult patients aged 18 to 60 years with certain health criteria. It aims to determine which method, nasal CPAP mask or nasal airway, may offer better results during dental procedures where sedation is necessary due to high fear and anxiety levels. The study involves 60 patients divided into two groups: one receiving ventilation support via a nasal CPAP mask and the other via a nasal airway. Before the procedure, patients receive anxiolysis with intravenous midazolam, followed by sedation induction with propofol and fentanyl. Ventilation support is provided non-invasively using the assigned airway device, and sedation is maintained with sevoflurane inhalation. The dental extraction surgery lasts between 20 and 60 minutes. Postoperative pain relief is managed with intravenous paracetamol and dexketoprofen trometamol. Throughout the procedure and for four hours afterward, researchers monitor vital signs such as blood pressure, heart rate, oxygen saturation, respiratory rate, and ventilation parameters including tidal volume, minute volume, end tidal CO2, and peak pressure. They also track anesthesia interruptions and sedation levels. After surgery, assessments of nausea, nasal and throat discomfort, and patient and surgeon satisfaction scores are collected. This detailed monitoring helps evaluate safety, comfort, and effectiveness of the two ventilation methods during deep sedation.

This research evaluates how different inspiratory to expiratory (I:E) ratios, specifically 1:2 versus 1:3, affect respiratory function and recovery during dental procedures performed under general anesthesia in children aged 2 to 12 years. Because some children have behavioral challenges, dental phobia, or medical conditions, general anesthesia is used to ensure they remain still and cooperative during treatment. The study aims to optimize ventilation strategies to improve patient comfort and safety during the emergence from anesthesia. The study observes routine clinical care where the I:E ratio is adjusted about 20 to 30 minutes before the procedure ends to help patients transition smoothly to breathing on their own. No additional treatments or interventions are applied beyond standard anesthesia and dental care. Researchers use a non-invasive scoring system during the emergence phase to assess respiratory quality based on breathing patterns, muscle use, airway openness, reactions to pain, and coughing. Two different I:E ratios are compared to see their effects on breathing and recovery. Participants will be monitored for vital signs including heart rate, blood pressure, oxygen saturation, exhaled carbon dioxide levels, respiratory rate, and peak airway pressure during emergence. Recovery quality is assessed using physical responses during airway suctioning and extubation, signs of airway spasms, agitation levels measured by anxiety and delirium scales, and discharge times from recovery and hospital wards. All data are recorded without changing standard anesthesia or dental treatment protocols, ensuring a natural observation of respiratory and recovery outcomes.

Researchers are comparing three treatment methods for peri-implantitis, a condition affecting the tissue around dental implants. The study evaluates mechanical debridement, Er:YAG laser decontamination, and Diode laser decontamination to see which is more effective at reducing the depth of the peri-implant sulcus. This evaluation focuses on patients aged 40 to 60 years who have specific signs of peri-implantitis such as probing depth and bone loss. The study involves three groups receiving different treatments: one group will have a single session of subgingival mechanical debridement, while the other two groups will undergo three sessions each of laser decontamination using either Er:YAG or Diode lasers. These treatments are applied non-surgically to the affected implant areas. Participants will be monitored for changes in probing depth and clinical attachment loss six months after treatment. The study will measure how well each treatment reduces these clinical signs of inflammation and tissue damage around the implants. This monitoring helps assess the effectiveness of each approach in managing peri-implantitis over time.

Researchers are evaluating motor skills, balance, dual task performance, and social adaptation abilities in children and young adults with autism spectrum disorder compared to individuals with typical motor development. The study is conducted at Bartın Lider Special Education and Rehabilitation Center and aims to compare these skills using specific assessment scales to better understand functional differences between these groups. Participants will be divided into two groups: those with autism spectrum disorder and those with normal motor development. Various tests will be used including the 10 meter walk test with added motor and cognitive tasks to assess dual task abilities, the Timed Up and Go (TUG) test to measure functional balance, the Vineland Adaptive Behavior Scales to evaluate social adaptation through parent interviews, and the Bruininks-Oseretsky Motor Proficiency Test (BOT-2) to assess fine and gross motor skills, coordination, strength, and agility. Participants will provide socio-demographic information such as age, height, weight, body mass index, education level, exercise, and smoking habits. Researchers will measure motor skills, balance, dual task performance, and social adaptation through timed tests and standardized scales. The main outcome includes the 10 meter walk test at enrollment. The study involves children and young adults aged 4 to 21 years and includes assessments conducted at the special education and rehabilitation center.