East Hanover

Researchers are evaluating a new combined approach to improve learning and memory in adults with multiple sclerosis (MS) who have mobility disability. This study focuses on how combining a cognitive rehabilitation technique with exercise programs may enhance new learning and memory, addressing limitations seen when using cognitive rehabilitation alone. This approach aims for a more complete recovery of memory function in people with MS. The study uses the Kessler Foundation modified Story Memory Technique (KF-mSMT), a memory retraining method involving imagery and context skills. Participants will receive 10 sessions of KF-mSMT over 5 weeks, with two sessions per week lasting 45 to 60 minutes each. They will also be assigned to one of two exercise programs: Aerobic Exercise Training with virtual reality cycling for 12 weeks or supervised stretching and toning targeting various body areas for 12 weeks. Participants will be assessed before and after the interventions for changes in new learning and memory abilities, including everyday memory. The study includes tests and questionnaires to monitor cognitive function and physical activity levels. The total participation period includes pre-intervention assessments during weeks 1 and 2 and post-intervention assessments during weeks 15 and 16, with safety and cognitive status monitored throughout.

This research aims to test whether a cognitive training program can improve processing speed abilities in people who have recently experienced an acute traumatic spinal cord injury (SCI). SCI affects about 18,000 individuals annually in the US, and while physical limitations and therapies have been studied extensively, cognitive difficulties such as attention, memory, and processing speed are less understood. These cognitive issues can impact employment, social activities, daily tasks, and mental health, making recovery and rehabilitation more challenging. This study focuses on early intervention to potentially improve overall health and well-being after SCI. Participants will engage in game-like computerized activities designed as a cognitive training program or a placebo version of similar game-like activities. The study compares these two behavioral interventions to evaluate changes in cognitive processing speed shortly after injury. This pilot study is multisite and targets individuals approximately within six months post-injury. During the study, participants' cognitive abilities will be assessed using tests like the Useful Field of View (UFOV), Letter & Pattern Comparison (LPC), and Symbol Digit Modalities Test (SDMT) at baseline, immediately after treatment (week 13), and at a long-term follow-up (week 25). Researchers will monitor changes in processing speed and cognitive function over time to understand the impact of the training. The total participation involves these assessments and intervention periods to track cognitive improvements and safety.

Researchers are conducting a United States-based, prospective, non-interventional study to evaluate the real-world effectiveness and patient-centered outcomes of remibrutinib in adults with chronic spontaneous urticaria (CSU). The study focuses on measuring changes in symptoms and disease control using validated patient-reported outcome tools. This research aims to understand how remibrutinib performs in routine clinical practice outside of controlled clinical trials. The study observes patients who have been prescribed remibrutinib or dupilumab and are expected to start treatment. There are no experimental treatments or interventions administered by the study team, as it is non-interventional. Participants must have access to electronic devices with internet to report outcomes and complete surveys related to their condition and treatment experience. Participants will be involved in providing information through validated questionnaires, including the Urticaria Control Test (UCT) to assess symptom control at baseline and after four weeks of treatment. Researchers will monitor patient satisfaction and treatment effectiveness over time by collecting patient-reported data remotely. The total participation duration includes the initial four-week period after treatment initiation where primary outcomes are measured.

This research aims to evaluate how well a training program focused on personal strengths can help young adults with autism improve their ability to keep a job and feel more satisfied at work. People with autism often have valuable strengths but face challenges in finding and maintaining employment. Unlike traditional programs that focus on fixing weaknesses, this study explores a new strength-based approach designed to support autistic individuals by building on their existing abilities. The program being tested, called KF-STRIDE®, was originally developed to improve job interview skills and is now being adapted to focus on job maintenance skills. Participants in the treatment group will take part in 10 web-based sessions of the KF-STRIDE® Into Work! program, which are offered once or twice a week and last about 60 minutes each. These sessions use a strength-based training tool to help participants identify and express their personal strengths related to maintaining employment. This behavioral intervention is delivered online, allowing participants to engage in the program remotely. During the study, researchers will assess participants at the start and immediately after the program (between weeks 7 and 8) using several questionnaires and scales. These include measures of work self-efficacy, strengths knowledge and use, overall flourishing, and participants' own impressions of change and program effectiveness. This will help evaluate how the strength-based training impacts job maintenance skills and satisfaction. The study focuses on young adults aged 14 to 26 who live in the United States and speak English well enough to participate.

Researchers are evaluating a strength-based web intervention called KF-STRIDE designed to help young adults with Autism Spectrum Disorder improve their job interview skills. This study focuses on those who may struggle with interviews and want to enhance their ability to communicate their unique strengths to potential employers. The intervention is rooted in positive psychology and aims to increase users' understanding of their personal strengths and improve interview performance in a real-world community setting. Participants in the treatment group will complete 10 web-based sessions of KF-STRIDE, each lasting about 60 minutes, held once or twice a week. The program helps users identify their employable strengths and practice discussing these strengths in socially appropriate ways. The intervention will be delivered by trained staff at Spectrum Works, a community partner that provides job training and employment support for autistic youth. During the study, participants will complete assessments such as mock job interviews, employment status checks, and various scales measuring knowledge, self-efficacy, anxiety, job search behavior, work readiness, and character strengths. These assessments occur at baseline, immediately after the intervention (between weeks 7 and 8), and at a 6-month follow-up. The study monitors participants' progress toward employment and evaluates the intervention's impact on job interview skills and readiness over time.

Researchers are evaluating a cognitive training program designed to improve processing speed in people who have recently experienced acute traumatic spinal cord injury (SCI). SCI affects about 18,000 people in the US each year, and while physical challenges have been well studied, cognitive problems like attention, memory, and slowed information processing are common but less addressed. These cognitive difficulties can negatively impact employment, social activities, daily tasks, mental health, and overall rehabilitation outcomes. This pilot study aims to see if early cognitive training can positively influence recovery and quality of life for those with SCI. Participants will engage in game-like computerized activities intended to train and improve their processing speed. The study involves a multisite pilot approach focusing on early intervention shortly after the injury. The computerized training will be delivered repeatedly over a set period to assess its effects on cognitive processing speed in individuals with acute SCI. Throughout the study, participants' cognitive function will be assessed at baseline, immediately after treatment (week 13), and at a long-term follow-up (week 25). Key measures include the Useful Field of View (UFOV), Letter and Pattern Comparison (LPC), and Symbol Digit Modalities Test (SDMT). Researchers will monitor changes in these tests to evaluate the program's impact on cognitive abilities. The overall study duration and follow-up aim to capture both immediate and sustained effects of the training.

Researchers are evaluating two web-based intervention programs designed to improve well-being and self-concept in adults who have experienced moderate to severe traumatic brain injury (TBI). This study focuses on the Signature Strengths program, which aims to help participants recognize and use their personal strengths to enhance coping and maintain improved outcomes over time. The trial compares this approach with a TBI Education Course based on established knowledge from the TBI Model Systems Knowledge Translation Center. Participants are randomly assigned to one of two groups: the Signature Strengths intervention or the TBI Education Course. Each group completes six weekly web-based sessions lasting about 60 minutes each. The Signature Strengths program follows an Aware-Explore-Apply framework to teach participants how to identify and apply their key strengths in daily life. The TBI Education Course offers factual lessons about TBI and its management. Throughout the study, participants will be assessed using various self-report tools including the Rosenberg Self-Esteem Scale, the Strengths Knowledge and Strengths Use Scale, the Head Injury Semantic Differential Scale, the Global Assessment of Character Strengths, and the Twenty-Statements Task. These assessments occur at baseline, three months after the intervention, and six months after the intervention to measure changes in well-being, self-concept, and related outcomes. The total duration of participation includes these follow-up periods to monitor lasting effects.

This research aims to understand the full range of symptoms, treatment use, and overall quality of life experienced by people with C3 glomerulopathy (C3G) and their caregivers. It focuses on collecting real-world data over time, especially from home-reported outcomes about symptom burden and treatment, including those taking iptacopan. The study is observational and prospective, seeking to capture changes and variability in symptoms and health-related quality of life as reported directly by patients and caregivers. Participants will enroll and take part using the Folia Health mobile app, which they use to report symptoms, treatments, and quality of life measures monthly for an initial period of six months. They will track routine treatments, symptom changes, and treatment plan adjustments through the app. After six months, participants may choose to continue contributing data by reconsenting. The study also plans to link other real-world data sources such as electronic health records, claims, or wearable device data to enrich the collected information. Throughout the study, participants will complete monthly surveys and provide patient-reported outcomes via the app. The collected data will be tokenized and could be integrated into Novartis data platforms for further analysis. Researchers will measure symptom frequency, severity, and variability over six months, alongside treatment patterns and quality of life. Participants must have access to a mobile device and be able to use the app to contribute data during the study period.

Researchers are studying Paroxysmal Nocturnal Hemoglobinuria (PNH) to better understand the wide range of symptoms, treatment use, and overall health-related quality of life experienced by patients. The focus is on collecting real-world data using home-reported outcomes and patient-reported measures, including those who take oral iptacopan, to capture how symptoms and quality of life vary over time. Participants will enroll in this prospective observational study for six months, using the Folia mobile app to provide consent and report their routine treatments, symptoms, treatment changes, and quality of life. Recruitment will be through clinics and community sources. Monthly surveys will gather additional data, and there may be integration with electronic health records or claims data. Treatment decisions, including the use of therapies like eculizumab, ravulizumab, pegcetacoplan, or iptacopan, will follow usual clinical care and are not controlled by the study. During the study, participants will regularly use the app to report their symptom burden and treatment use. Monthly check-ins will help track changes, and researchers will measure symptom burden at the start and after six months. The study aims to develop a new source of real-world data to improve understanding of PNH symptoms, treatment patterns, and quality of life in US patients.

Researchers are evaluating a computer-based cognitive training program aimed at improving learning and memory in individuals with multiple sclerosis (MS). Cognitive impairments are common in MS and are linked to difficulties like unemployment, poor quality of life, and driving challenges. This study focuses on a treatment that has shown effectiveness in enhancing cognitive performance, daily functioning, and brain imaging results in people with MS. To overcome the barrier of traveling to clinics, this pilot study tests the feasibility of delivering the training remotely via Zoom Health. Participants will be assigned to one of two groups: the experimental group receiving memory retraining exercises, or a sham comparator group receiving placebo memory exercises. Both groups will complete ten sessions, held twice a week over five weeks, using a laptop computer and Zoom Health for remote administration. This approach aims to provide accessible cognitive training for people with MS living in the community. During the study, participants' cognitive abilities will be assessed using the California Learning Verbal Test III at baseline (one week before starting training) and immediately after completing the training sessions. Researchers will monitor participants' memory performance to evaluate the impact of the training. The study includes careful screening to ensure participants meet eligibility criteria and to monitor safety throughout the treatment period.