Combining Cognitive Rehabilitation with Exercise to Improve Learning and Memory in Adults with Multiple Sclerosis

What this Trial Is About

Researchers are evaluating a new combined approach to improve new learning and memory NLM in people with multiple sclerosis pwMS who have mobility difficulties. This study looks at how combining cognitive rehabilitation using the Kessler Foundation modified Story Memory Technique KF-mSMT, a memory retraining program, with exercise may enhance recovery more than cognitive rehabilitation alone. The study aims to maximize functional recovery by addressing the limitations of cognitive rehabilitation when used by itself. Participants will be randomly assigned to one of two groups. One group will complete a supervised aerobic exercise training program with virtual reality IDEAL three days a week for 12 weeks for the first seven weeks, they do only the exercise, and for weeks 8 to 12, they also do the KF-mSMT memory program two days a week. The other group will do supervised stretching and toning exercises three days a week for 12 weeks, with the same schedule of adding KF-mSMT during weeks 8 to 12. Both interventions are supervised and aim to improve memory and physical activity. Participants will be assessed before the intervention weeks 1 and 2 and after the intervention weeks 15 and 16 to measure changes in objective learning and memory, everyday memory, and brain changes such as hippocampal volume and function. The study includes questionnaires and memory tests, with safety and progress monitored throughout. Participation lasts about 16 weeks in total, including the treatment and follow-up assessments.

A Novel Combinatory Approach to Maximize Functional Recovery of Learning and Memory in Multiple Sclerosis