Actively Recruiting
Long Term Cardiovascular Disease Event Risk for Patients Undergoing Major Non-Cardiac Surgery
Led by University Health Network, Toronto · Updated on 2024-08-13
50
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to understand whether healthy lifestyle choices made around the time of major non-cardiac surgery can affect a person's long-term risk of developing cardiovascular disease. The study focuses on patients aged 45 to 75 years undergoing intermediate- to high-risk surgeries, including intra-thoracic, intra-abdominal, vascular, neurosurgery, and spine procedures. Researchers want to learn if surgery motivates patients to improve habits like diet and exercise and how these changes might influence cardiovascular risk over time. Participants will be observed during two main periods: one month before surgery and three months after surgery. Healthy lifestyle behaviors such as diet improvement and beginning exercise around the surgery time are monitored to see their impact on cardiovascular risk. The study does not involve experimental treatments but follows patients to assess natural changes in behavior and heart health risk. During the study, participants will undergo assessments to calculate their 10-year cardiovascular disease event risk before surgery and again three months after surgery. Researchers will also track any cardiovascular or non-cardiovascular events occurring within 30 days post-surgery. Participants are expected to have a hospital stay of at least two days. The study helps understand lifestyle changes and their effects on heart disease risk in surgical patients over time.
CONDITIONS
Brief Title
Long Term Cardiovascular Disease Event Risk for Patients Undergoing Major Non-Cardiac Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 45 to 75 years
- Scheduled for intermediate- to high-risk non-cardiac surgery including intra-thoracic, intra-abdominal, vascular, intra-cranial neurosurgery, or spine surgery
- Expected post-operative hospital stay of at least two days
- Have at least two cardiovascular risk factors such as hypertension, diabetes, coronary artery disease, chronic heart failure, chronic kidney disease, cerebrovascular disease, peripheral vascular disease, obesity (BMI >25), current smoking, or poor exercise capacity (<4 METS)
You will not qualify if you...
- Currently participating in a cardiovascular disease risk reduction program
- Scheduled for transplant surgery or emergency surgery
- Life expectancy less than 1 year (palliative surgery)
- Recent myocardial infarction or stroke within 6 months
- Surgery scheduled in less than 1 month
- Inability to communicate effectively
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - Up to 1 month before surgery
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 month before surgery
Baseline assessments are conducted to calculate the pre-operative 10-year cardiovascular disease event risk.
1 visit (in-person)
Duration - At least 2 days
Participants undergo intermediate- to high-risk non-cardiac surgery and receive immediate post-operative care during hospitalization.
Hospital stay for surgery and immediate care
Duration - Up to 3 months after surgery
Follow-up assessments occur to calculate post-operative cardiovascular disease risk and monitor any cardiovascular or non-cardiovascular events.
2 visits (1 at 30 days and 1 at 3 months post-surgery, in-person)
Duration - Beyond 3 months after surgery
Participants are observed for long-term changes in lifestyle behaviors around the time of surgery and their influence on cardiovascular risk.
Follow-up visits as scheduled depending on individual risk and study protocol
Trial Site Locations
Total: 1 location
1
Toronto General Hospital
Toronto, Ontario, Canada, M5G 2C4
Actively Recruiting
Research Team
W
Wilton van Klei, MD
M
Marc Sicova
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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