Actively Recruiting

Age: 18Years +
All Genders
ID06782165

Long-term Follow-up of Temporomandibular Joint Surgery and Evaluation of the 6-month Control as a Prognostic Marker

Led by Karolinska Institutet · Updated on 2025-12-17

91

Participants Needed

1

Research Sites

12 weeks

Total Duration

On this page

Sponsors

K

Karolinska Institutet

Lead Sponsor

K

Karolinska University Hospital

Collaborating Sponsor

AI-Summary

What this Trial Is About

Researchers are evaluating the long-term outcomes of surgical treatment for temporomandibular joint (TMJ) disc displacement, either with reduction (DDwR) or without reduction (DDwoR). The study focuses on whether the surgical results seen six months after surgery remain stable about 10 years later, and how joint degeneration changes over time after surgery. This research addresses a gap in knowledge about the long-term effects of TMJ surgeries such as arthroscopy and discectomy, which have previously been studied mostly over shorter periods. The study involves patients who had TMJ surgery between 2014 and 2017, including arthroscopic lysis and lavage with saline irrigation or open discectomy where the joint disc is completely removed. These patients will be invited for a follow-up clinical examination and a cone-beam computed tomography (CBCT) scan of the TMJ approximately 10 years after their surgery. The examination will assess both subjective outcomes like pain and disability and objective measures such as mouth opening and joint movement. Participants will undergo a one-time visit lasting about 30 minutes for clinical evaluation and imaging. Researchers will collect data on mouth opening capacity, patient-reported pain and disability, and radiological changes compared to initial scans before surgery. The study aims to identify predictors of long-term surgical success and examine how joint degeneration correlates with clinical outcomes. All scans will be reviewed by a radiology specialist, and findings may influence future follow-up protocols. The study is observational and does not involve additional treatments.

CONDITIONS

Brief Title

Long-term Follow up of TMJ Surgery and Evaluation of the 6-month Control as a Prognostic Marker.

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients who participated in the previous studies with ethical approval numbers EPN 2014/764-31/2 and 2014/622-31/1
  • Individuals diagnosed with temporomandibular joint disc displacement with reduction (DDwR) or without reduction (DDwoR)
  • Adults aged 18 years or older
Not Eligible

You will not qualify if you...

  • Patients unable to provide informed consent

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Surgery and Immediate Post-operative Care

Duration - Occurs between 2014 and 2017

Participants underwent arthroscopy or discectomy surgery of the temporomandibular joint between 2014 and 2017.

Surgery visit (in-person)

Post-operative Follow-up

Duration - 6 months

Participants were followed up for six months post-surgery to assess early surgical outcomes including mouth opening capacity, TMJ pain, and disability.

Multiple visits during 6-month postoperative period

Long-term Monitoring

Duration - Approximately 1 day for clinical and radiological examination scheduled in 2025

Participants are invited for a clinical and radiological examination approximately 10 years after surgery to evaluate long-term surgical outcomes and joint status.

1 visit (in-person) including clinical assessment and CBCT radiological examination

Trial Site Locations

Total: 1 location

1

Karolinska Institutet

Huddinge, Sweden, 14104

Actively Recruiting

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Research Team

M

Mattias Ulmner, DDS, PhD

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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Published Research Related To This Trial

Synovial Tissue Proteins and Patient-Specific Variables as Predictive Factors for Temporomandibular Joint Surgery.

Mattias Ulmner, Rachael Sugars, Aron Naimi-Akbar...

https://pubmed.ncbi.nlm.nih.gov/33396653

Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) for Clinical and Research Applications: recommendations of the International RDC/TMD Consortium Network* and Orofacial Pain Special Interest Group†.

Eric Schiffman, Richard Ohrbach, Edmond Truelove...

https://pubmed.ncbi.nlm.nih.gov/24482784

Temporomandibular joints in asymptomatic and symptomatic nonpatient volunteers: a prospective 15-year follow-up clinical and MR imaging study.

Hanna Salé, Fredrik Bryndahl, Annika Isberg

https://pubmed.ncbi.nlm.nih.gov/23249569

Outcome of arthroscopic surgery to the temporomandibular joint correlates with stage of internal derangement: five-year follow-up study.

K I Murakami, Y Tsuboi, K Bessho...

https://pubmed.ncbi.nlm.nih.gov/9578253