Effects of Daily Ataulfo Mango Intake on Gut, Inflammation, and Cardiometabolic Health in HispanicLatino Adolescents Aged 12 to 19

What this Trial Is About

Researchers are evaluating how daily consumption of mangos affects gut and metabolic health in HispanicLatino adolescents aged 12 to 19 years who have a higher risk of cardiovascular issues due to overweight or obesity. This study compares the effects of replacing typical high-calorie, low-nutrient snacks with mangos in this important minority group, aiming to understand how mango-derived nutrients and microbial metabolites influence physiological responses. The study is a randomized, controlled 2-arm crossover trial involving 25 adolescents. Participants will be assigned to consume either three-quarters of a cup of Ataulfo mango daily or continue their usual diet without mangos for 4 weeks. After a 4-week washout, they will switch to the alternate group. The mango will be served as uniform chunks or blended into smoothies to fit into their habitual diets. During the study, participants will be monitored for microvascular function and various secondary health markers such as cytokines, short chain fatty acids, bile acids, zonulin, lipopolysaccharide binding protein, CD14, GLP-1, plasma lipids, and IGFIGFbp after 4 weeks of each diet phase. Smartphone or tablet use will be required for daily photo tracking of the consumed products. The total duration includes two 4-week intervention periods separated by a washout, with detailed assessments to understand the impact of mango intake on cardiometabolic and inflammatory health indicators.

Mango Intake and Gut and Cardiometabolic Health in Hispanic/Latino Adolescents