Actively Recruiting
The Influence of Mango-Derived Intestinal Microbial Metabolites on Gut Permeability, Inflammation, and Cardiometabolic Health Markers in Hispanic/Latino Adolescents
Led by University of California, Davis · Updated on 2026-02-03
25
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating how daily consumption of mangos affects gut and metabolic health in Hispanic/Latino adolescents aged 12 to 19 years who have a higher risk of cardiovascular issues due to overweight or obesity. This study compares the effects of replacing typical high-calorie, low-nutrient snacks with mangos in this important minority group, aiming to understand how mango-derived nutrients and microbial metabolites influence physiological responses. The study is a randomized, controlled 2-arm crossover trial involving 25 adolescents. Participants will be assigned to consume either three-quarters of a cup of Ataulfo mango daily or continue their usual diet without mangos for 4 weeks. After a 4-week washout, they will switch to the alternate group. The mango will be served as uniform chunks or blended into smoothies to fit into their habitual diets. During the study, participants will be monitored for microvascular function and various secondary health markers such as cytokines, short chain fatty acids, bile acids, zonulin, lipopolysaccharide binding protein, CD14, GLP-1, plasma lipids, and IGF/IGFbp after 4 weeks of each diet phase. Smartphone or tablet use will be required for daily photo tracking of the consumed products. The total duration includes two 4-week intervention periods separated by a washout, with detailed assessments to understand the impact of mango intake on cardiometabolic and inflammatory health indicators.
CONDITIONS
Brief Title
Mango Intake and Gut and Cardiometabolic Health in Hispanic/Latino Adolescents
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 12 to 19 years
- Body mass index (BMI) at or above the 85th percentile for age and sex
- Self-identify as Hispanic or Latino
- Willing and able to follow the study protocols
- Willing to consume the study products
- If female and menstruating, must have regular menstrual cycles of 25-30 days
- Access to a smartphone or tablet daily to take pictures of consumed products
You will not qualify if you...
- Reported food allergies
- Taking prescription drugs except asthma inhalers
- BMI below the 85th percentile for age and sex
- Currently engaged in moderate or high-intensity daily exercise
- Self-reported serious illness or under acute medical care
- Use of supplements such as multivitamins, herbal, plant, fish oil, or oil supplements without willingness to stop before study
- Following a vegetarian or vegan diet
- Self-reported malabsorption or gastrointestinal issues
- Fruit and vegetable intake exceeding five servings daily
- Smoking (including vaping, nicotine products, or marijuana)
- Currently enrolled in another clinical research study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 4 weeks per intervention period with a 4-week washout period between
Participants consume either ¾ cups of Ataulfo mango daily or continue their habitual diet for 4 weeks, followed by a 4-week washout period before switching to the alternate group.
Visits occur at the start and end of each dietary intervention period
Trial Site Locations
Total: 1 location
1
Academic Surge; Ragle Human Nutrition Research Center
Davis, California, United States, 95616
Actively Recruiting
Research Team
R
Roberta R Holt, PhD
G
Genesis G Guerra Gaitan, MS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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