Study of Genetic Variations in Cytokine Genes and Their Impact on Type 2 Inflammatory Asthma in Children Age 3 to 14

What this Trial Is About

Researchers are investigating how genetic differences called single nucleotide polymorphisms SNPs affect children with type 2 inflammation-related asthma. This observational study compares children diagnosed with asthma who show signs of type 2 inflammation to healthy children. The goal is to better understand how these genetic variations influence asthma development and to support personalized treatment and prevention strategies. The study includes two groups children with asthma who meet specific inflammation criteria and healthy children. Researchers measure several type 2 inflammation markers, such as the fraction of exhaled nitric oxide, blood eosinophil counts, sputum eosinophil percentages, and serum immunoglobulin E levels. They also assess lung function through tests like forced expiratory volume in one second FEV1, forced vital capacity FVC, FEV1FVC ratio, and peak expiratory flow PEF. Genetic testing for SNPs is performed to explore differences between groups. Participants will be evaluated during outpatient visits, where lung function tests and inflammation marker measurements will be collected. The main outcomes include type 2 inflammation indicators, pulmonary function measures, and genetic polymorphism data. This process helps researchers identify risk factors and differences in asthma linked to genetics, with the study lasting until December 2025.

Association Between Genetic Polymorphisms and Type 2 Asthma in Children