Actively Recruiting

FEMALE
Healthy Volunteers
NCT03276923

Maternal Autoimmune Disease Research Alliance (MADRA) Registry

Led by Duke University · Updated on 2026-01-08

1000

Participants Needed

1

Research Sites

469 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This multi-site registry, centered at Duke University, will enroll pregnant women with autoimmune and rheumatologic diseases. The main goal of MADRA is to identify ways to improve the health of women with rheumatic diseases and their babies during pregnancy. Prior studies demonstrate the importance of increase inflammation prior to and during pregnancy on these outcomes. The future research will seek to better define these risk factors and to identify ways to may improve them.

CONDITIONS

Official Title

Maternal Autoimmune Disease Research Alliance (MADRA) Registry

Who Can Participate

FEMALE
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Desire for pregnancy within 6 months or currently pregnant
  • Women with systemic autoimmune diseases including lupus (systemic lupus erythematosus or cutaneous lupus)
  • Women with antiphospholipid syndrome or positive antiphospholipid antibodies
  • Women with rheumatoid arthritis
  • Women with scleroderma (systemic sclerosis)
  • Women with Sjogren's syndrome
  • Women with inflammatory arthritis including psoriatic arthritis and ankylosing spondylitis
  • Women with undifferentiated connective tissue disease (UCTD)
  • Women with vasculitis
  • Women with myositis (polymyositis or dermatomyositis)
  • Women with positive Ro/SSA or La/SSB antibodies
Not Eligible

You will not qualify if you...

  • Unable to speak English
  • Unable to provide informed consent
  • Unable to travel to Duke University for follow-up visits

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Duke University

Durham, North Carolina, United States, 27705

Actively Recruiting

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Research Team

L

Laura Neil

CONTACT

E

Edna Scarlett

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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