Studying Kidney Blood Flow and Inflammation in Adults Over 30 with Severe Infections and Acute Kidney Injury Using PET-CT Scans

What this Trial Is About

Researchers are investigating kidney blood flow and inflammation caused by neutrophils in patients with sepsis who also have acute kidney injury AKI. The study uses positron emission tomography PET to measure how blood moves through the kidneys and to detect neutrophil elastase, an indicator of neutrophil presence and inflammation. This research includes both critically ill patients with sepsis and AKI and healthy volunteers for comparison. During the study, participants undergo PET scans using marked water to assess kidney blood flow and a new PET tracer molecule called 11C-GW457427 to measure neutrophil elastase in the kidney tissue. A CT scan is performed at the same time to provide anatomical images. Blood samples are also taken to measure inflammatory mediators, and clinical information is collected from each participant. Participants are examined once with these imaging techniques within 10 days of AKI diagnosis. Researchers monitor kidney blood flow and neutrophil elastase presence as the main outcomes. The study involves 10 patients with sepsis and AKI and 5 healthy volunteers. Safety and clinical data are continuously evaluated, with the study expected to complete by June 2026.

Mechanisms of Acute Kidney Injury in Severe Infections