Actively Recruiting
Mechanisms of Acute Kidney Injury in Severe Infections
Led by Uppsala University Hospital · Updated on 2024-12-06
15
Participants Needed
1
Research Sites
112 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Renal perfusion and neutrophil-mediated inflammation will be assessed in the kidney in sepsis patients with acute kidney injury using positron emission tomography. For marked water will be used for renal perfusion and a newly developed PET tracer molecule (11C-GW457427) with specific binding to neutrophil elastase which provides a measure of the amount of infiltrating neutrophils in the renal parenchyma for inflammation. The study is performed in a PET-CT camera where anatomical imaging takes place at the same time as the PET examinations.
CONDITIONS
Official Title
Mechanisms of Acute Kidney Injury in Severe Infections
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with sepsis and acute kidney injury (AKI)
- Age over 30 years
- At least AKI stage 1 according to KDIGO with last plasma creatinine measured within 24 hours before examination
- Healthy volunteers over 30 years old
- No previously known kidney disease for healthy volunteers
- Normal plasma creatinine value for healthy volunteers
You will not qualify if you...
- Chronic renal failure (CKD stage greater than 3a) or dialysis
- Unstable vital signs making PET-CT examination unsuitable
- Claustrophobia or inability to lie still during examination
- Pregnancy or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Uppsala university hospital
Uppsala, Sweden, 75185
Actively Recruiting
Research Team
M
Miklos Lipcsey, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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