Actively Recruiting
Mechanisms of Acute Kidney Injury in Severe Infections using Positron Emission Tomography
Led by Uppsala University Hospital · Updated on 2024-12-06
15
Participants Needed
1
Research Sites
12 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating kidney blood flow and inflammation caused by neutrophils in patients with sepsis who also have acute kidney injury (AKI). The study uses positron emission tomography (PET) to measure how blood moves through the kidneys and to detect neutrophil elastase, an indicator of neutrophil presence and inflammation. This research includes both critically ill patients with sepsis and AKI and healthy volunteers for comparison. During the study, participants undergo PET scans using marked water to assess kidney blood flow and a new PET tracer molecule called 11C-GW457427 to measure neutrophil elastase in the kidney tissue. A CT scan is performed at the same time to provide anatomical images. Blood samples are also taken to measure inflammatory mediators, and clinical information is collected from each participant. Participants are examined once with these imaging techniques within 10 days of AKI diagnosis. Researchers monitor kidney blood flow and neutrophil elastase presence as the main outcomes. The study involves 10 patients with sepsis and AKI and 5 healthy volunteers. Safety and clinical data are continuously evaluated, with the study expected to complete by June 2026.
CONDITIONS
Brief Title
Mechanisms of Acute Kidney Injury in Severe Infections
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with sepsis and acute kidney injury (AKI) aged over 30 years
- AKI at least stage 1 according to KDIGO with plasma creatinine measured within 24 hours before examination
- Healthy volunteers over 30 years old
- Healthy volunteers with no known kidney disease
- Healthy volunteers with normal plasma creatinine values
You will not qualify if you...
- Chronic kidney disease stage higher than 3a or on dialysis
- Instability in vital functions making PET-CT unsuitable
- Claustrophobia or inability to lie still during examination
- Pregnancy or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Within 10 days of acute kidney injury diagnosis for patients
Participants undergo positron emission tomography (PET) scans with marked water and neutrophil elastase tracer along with a CT scan to assess kidney function and inflammation.
1 visit (in-person)
Duration - Single time point observation following diagnostic evaluation
Clinical data and plasma levels of inflammatory mediators are collected to observe changes in renal perfusion and inflammation.
No additional visits required
Trial Site Locations
Total: 1 location
1
Uppsala university hospital
Uppsala, Sweden, 75185
Actively Recruiting
Research Team
M
Miklos Lipcsey, MD, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here