Using Metagenomic Sequencing to Detect Infections in Adults with Ocular Inflammation

What this Trial Is About

Researchers are evaluating the use of metagenomic sequencing to detect infections in patients with ocular inflammation when standard tests have failed to find a cause. Many people with this eye condition have unknown origins, and sometimes an infection or infection-triggered autoimmune response is suspected but not identified by current methods. This study aims to improve diagnosis and treatment understanding by applying a test previously optimized for brain infections to eye fluid samples. Participants will have fluid samples taken from inside their eyes as part of their usual care, which will then be tested using metagenomic sequencing alongside standard diagnostic tests. They will also undergo additional non-invasive eye imaging techniques during their clinic visit. This study is observational and will last about one year, with no extra research visits required beyond routine care. During the study, participants eye fluid samples and imaging results will be analyzed to see how often metagenomic sequencing provides useful clinical information. Researchers will track how many patients receive results that lead to changes in treatment and beneficial outcomes. Participants will only attend their regular clinic visits, and no additional visits are needed. The study will assess outcomes over a 12-month period to understand the potential of this diagnostic approach.

Metagenomics for Ocular Inflammation