Actively Recruiting
The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study
Led by Brigham and Women's Hospital · Updated on 2026-05-05
1000
Participants Needed
11
Research Sites
191 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to investigate whether symptoms of chest pain or shortness of breath among the study population are arising due to a heart problem, particularly any reduction of blood flow to the heart muscle from blockages in the coronary blood vessels or inflammation of the heart using cardiac magnetic resonance imaging that measures the amount of blood flow during a stress state meant to simulate vigorous exercise. At present, doctors use standard magnetic resonance imaging pictures of blood flow patterns to treat heart disease. The investigators want to study if detailed blood flow measurements, in addition to the standard blood flow pattern, could diagnose heart disease more accurately and allow more doctors to understand the severity of heart disease. Early research has demonstrated that detailed blood flow measurements may be more accurate in diagnosing heart disease in some patients, but doctors need more information to know how to use these measurements.
CONDITIONS
Official Title
The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 35 to 85 years
- Presence of chest pain, anginal equivalent, or abnormal electrocardiogram suspicious for coronary artery disease
- Intermediate or high risk of significant coronary disease based on at least one of the following: age over 45 for males or over 50 for females; history or treatment of diabetes, hypertension, or high cholesterol; family history of premature coronary disease (first degree relative male 55 or younger, female 65 or younger); history of smoking over 10 pack-years; post-menopausal state over 5 years; any chronic inflammatory conditions; body mass index over 30; or medical documentation of coronary or peripheral artery disease
You will not qualify if you...
- Acute myocardial infarction within 30 days before cardiac magnetic resonance imaging
- Severe valvular heart disease
- Left ventricular ejection fraction below 40% from non-coronary causes
- Infiltrative or hypertrophic cardiomyopathy
- Pericardial disease with significant constriction
- Active pregnancy
- Any condition expected to limit survival to less than 2 years
- Contraindication to vasodilator drugs (regadenoson or adenosine)
- Presence of metallic device or object posing magnetic resonance imaging safety hazard
- Metallic device likely to cause non-diagnostic cardiac magnetic resonance images
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 11 locations
1
University of California San Francisco
San Francisco, California, United States, 94107
Actively Recruiting
2
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
3
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
Actively Recruiting
4
St. Francis Hospital and Heart Center
Roslyn, New York, United States, 11576
Actively Recruiting
5
Atrium Health - Sanger Heart & Vascular Institute
Charlotte, North Carolina, United States, 28204
Actively Recruiting
6
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Actively Recruiting
7
The Ohio State University
Columbus, Ohio, United States, 43210
Actively Recruiting
8
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37203
Actively Recruiting
9
Houston Methodist Hospital
Houston, Texas, United States, 77030
Actively Recruiting
10
University of Virginia
Charlottesville, Virginia, United States, 22908
Actively Recruiting
11
Virginia Commonwealth University
Richmond, Virginia, United States, 23298
Actively Recruiting
Research Team
R
Raymond Y Kwong, MD, MPH
CONTACT
B
Bobby Heydari, MD, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here