Actively Recruiting
Negative Emotionality and Epigenetics During Puberty
Led by International Research Training Group 2804 · Updated on 2024-11-15
100
Participants Needed
1
Research Sites
105 weeks
Total Duration
On this page
Sponsors
I
International Research Training Group 2804
Lead Sponsor
U
University Hospital Tuebingen
Collaborating Sponsor
AI-Summary
What this Trial Is About
Pubertal transition leads to enduring neuroendocrine changes along with changes in the epigenome. The prevalence of psychiatric disorders significantly increases in females compared to males after puberty. There is likely to be an interaction between epigenetics, hormones and neurophysiological processes during puberty, leading to the increased prevalence of mental disorders in females. This study aims to shed light on these interactions underlying the emerging sex differences after puberty. Specifically, it seeks to investigate the epigenetic modifications and subsequent changes in gene expression during the pubertal transition and their association with negative emotionality (e.g., acute stress response and depressive symptoms) at molecular, neuronal, subjective and physiological levels.
CONDITIONS
Official Title
Negative Emotionality and Epigenetics During Puberty
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy girls
- Aged 8 to 10 years with pubertal stage 1 or aged 15 to 17 years with pubertal stage 5
- Body mass index between 5th and 85th percentile for age
- Non-smokers
- Fluent in German
- Attending age-appropriate schools
You will not qualify if you...
- Neurological or psychiatric diseases
- Hormonal, metabolic, developmental, or chronic medical problems such as congenital disorders, precocious puberty, polycystic ovarian syndrome, diabetes, or congestive heart failure
- Hormonal, pharmacological, or psychotropic treatment within the last three months
- Participation in competitive or extreme sports
- Non-removable metal objects on or in the body
- Tattoos not compatible with MRI according to expert guidelines
- Hearing problems or increased sensitivity to loud noises
- Claustrophobia
- Surgery within the last three months
- Moderate or severe head injury
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Tuebingen; Department of Psychiatry & Psychotherapy; Tuebingen
Tübingen, Baden-Wurttemberg, Germany, 72076
Actively Recruiting
Research Team
V
Vanessa Nieratschker, Prof. Dr.
CONTACT
B
Birgit Derntl, Prof. Dr.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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