Actively Recruiting
Neuromodulation of Memory in Aging
Led by Duke University · Updated on 2025-10-14
150
Participants Needed
1
Research Sites
169 weeks
Total Duration
On this page
Sponsors
D
Duke University
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The proposed research will use closed-loop transcranial magnetic stimulation (TMS) based on individualized brain networks to establish parameters that can reliably control brain states. This will be tested in healthy aging and mild cognitive impairment (MCI) cohorts. The investigators will study network activation and neural oscillatory mechanisms underlying the network that regulates working memory and then target this network using closed-loop TMS to the Prefrontal Cortex. Investigators will measure the impact of TMS on working memory performance and task-based neural activity. The project will use brain stimulation and network modeling techniques to enhance working memory in healthy older adults and MCI and will demonstrate the value of closed-loop, network-guided TMS for future clinical applications.
CONDITIONS
Official Title
Neuromodulation of Memory in Aging
Who Can Participate
Eligibility Criteria
You may qualify if you...
- English speaking
- Willing to provide consent
You will not qualify if you...
- History of any Axis I DSM-V disorder, excluding major depressive disorder or generalized anxiety disorders
- Current history of substance abuse or dependence (excluding nicotine)
- Intracranial implants such as aneurysm clips, shunts, stimulators, cochlear implants, or electrodes
- Cardiac pacemakers or vagus nerve stimulation device
- Increased risk of seizure including prior epilepsy diagnosis, seizure disorder, increased intracranial pressure, or significant head trauma with loss of consciousness for 5 minutes or more
- Neurological disorders including space occupying brain lesion, history of seizures, cerebrovascular accident, fainting, cerebral aneurysm, dementia, Huntington chorea, multiple sclerosis
- Current use of medications known to lower seizure threshold or affect working memory
AI-Screening
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Trial Site Locations
Total: 1 location
1
Duke University Hospital
Durham, North Carolina, United States, 27710
Actively Recruiting
Research Team
S
Simon W Davis, PhD
CONTACT
E
Emily Finch, BA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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