Study of New Non-invasive Technology to Assess Retinal Structure and Function Including Retinal Imaging for Eye Conditions and Visual Function Tests

What this Trial Is About

Researchers are evaluating a new non-invasive technology to assess the structure and function inside the eye. The study focuses on retinal imaging to detect areas of abnormal structure and function in people with inner and outer retinal defects. This technology is compared to other visual function tests to better understand eye conditions such as ischemic optic neuropathy, branch retinal artery occlusion, hemianopia, Leber hereditary optic neuropathy, and acute zonal occult outer retinopathy. The study uses a device called LSFG-NAVI, which measures laser-speckle blood flow in ocular arteries and veins. Participants include healthy controls and patients with defined inner or outer retinal defects. The imaging is non-invasive and aims to detect changes in ocular blood flow and retinal function. The study plans to enroll up to 450 participants, including 50 healthy controls and 400 patients with retinal conditions. Participants will undergo retinal imaging and ocular blood flow measurements using the LSFG-NAVI device. Assessments focus on detecting abnormalities in retinal structure and function. The primary outcome measured is ocular blood flow on the day of the imaging. Mild cataracts are allowed, but significant cataracts or other media opacities that affect retinal imaging will exclude participation. The study includes adults aged 18 to 99 years and involves monitoring and comparing retinal function with other visual tests.

New Non-invasive Modalities for Assessing Retinal Structure and Function