Actively Recruiting
Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease
Led by The Cleveland Clinic · Updated on 2026-01-02
200
Participants Needed
1
Research Sites
316 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This project aims to validate sex-specific biologic signatures associated with aortic valve disease developed in a large multicenter CMR registry, using unsupervised phenomapping. The aim to use standard and advanced CMR techniques (MRF, DTI, chemical exchange transfer, and radiomics analysis) is to determine advanced CMR predictors of reverse remodeling following aortic valve surgery and develop sex-specific thresholds for risk. Infrastructure developed by this study will enable development of an innovative, scalable, sex-specific precision medicine cardiovascular imaging pipeline to determine overall risk and treatment response.
CONDITIONS
Official Title
Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 90 years
- Suspected moderate or severe (2-3+ or more) aortic regurgitation, or moderate or more aortic stenosis based on prior clinical history, echocardiogram, or cardiac MRI
You will not qualify if you...
- Acute traumatic cardiac injury
- Aortic dissection or aortic root rupture
- Congenital heart diseases such as patent ductus arteriosus, coarctation of aorta, atrial septal defect, and ventricular septal defect
- Presence of arteriovenous fistula or intracardiac shunts
- Contraindications to cardiac MRI, including MR-incompatible implants like pacemakers or defibrillators, or older types of cerebral aneurysm clips
- Weight over 440 lbs or very wide waist circumference
- Claustrophobia that may prevent tolerating the MRI exam
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Actively Recruiting
Research Team
D
Deborah Kwon, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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