Global Multicenter Study Observing Treatments for Unprotected Left Main Coronary Artery Disease

What this Trial Is About

Researchers are observing the long-term clinical outcomes of patients with unprotected left main coronary artery LMCA disease. This study aims to compare the results of three treatment approaches medical therapy, coronary stenting with drug-eluting stents DES, and coronary artery bypass grafting CABG in real-world daily practice. The study collects data from multiple centers across Korea and the Asia-Pacific region to better understand treatment effects in routine care settings. This multicenter registry will enroll approximately 5000 patients diagnosed with significant unprotected LMCA stenosis over 50% blockage by visual estimation. Participants will be followed prospectively to record their treatment courses and outcomes. The study does not assign treatments but observes patients undergoing medical therapy, PCI with DES, or CABG as decided by their doctors. Participants will be monitored for up to 10 years, with key outcomes including death, heart attacks, repeat vessel procedures, and cerebrovascular events. The primary outcome is a composite event rate measured at 2 years. Additional assessments include stent-related complications and rehospitalizations. Data collection will involve regular clinical follow-ups to capture these health events and understand the long-term effects of different treatment approaches.

Observational Study for Left Main Disease Treatment