Evaluation of Gum Disease in Adults with Rare Kidney Disorders, Lupus, and Other Kidney Conditions Compared to Healthy Individuals

What this Trial Is About

This research aims to assess the burden and variety of periodontal disease in adults with rare kidney disorders such as Alport syndrome, Fabry disease, tuberous sclerosis complex, and systemic lupus erythematosus SLE, compared to those with chronic kidney disease CKD of other causes and healthy population controls. It is a cross-sectional, case-control observational study designed to better understand how these diseases may affect oral health. Participants will undergo a single study visit that includes a thorough full-mouth periodontal examination by a trained dentist, a clinical questionnaire, and review of relevant nephrological and clinical data from their medical records. The study groups include patients with genetically or clinically confirmed rare kidney diseases, SLE with kidney involvement, CKD controls, and population controls without CKD. During the study visit, researchers will collect data on periodontitis prevalence, severity of periodontal disease, gingivitis, xerostomia, and disease-specific oral findings. They will analyze associations between oral health and clinical factors such as kidney function and immunosuppressive treatment exposure. This one-time evaluation aims to provide detailed information on periodontal health across these groups, with no further follow-up visits planned.

Periodontal Disease in Rare Renal Disorders (PERIO-RA-RE)