Personalized Surveillance and Treatment Study for Adults with Familial Adenomatous Polyposis After ProctoColectomy Surgery

What this Trial Is About

Researchers are evaluating a personalized surveillance and intervention protocol for patients with familial adenomatous polyposis FAP who have undergone prophylactic proctocolectomy. FAP causes numerous polyps in the colon and rectum, leading to nearly certain colorectal cancer if untreated. Surgery such as restorative proctocolectomy or subtotal colectomy is performed to reduce cancer risk, but lifelong monitoring is needed due to the risk of new adenomas developing in remaining tissues. This study aims to provide evidence for tailored endoscopic surveillance intervals to prevent advanced neoplasia by removing lesions early. Participants will follow a personalized endoscopic surveillance schedule with intervals ranging from 6 months to 2 years, based on the severity of their polyposis and endoscopic interventions performed. They will undergo regular endoscopic examinations to monitor and remove polyps larger than 5mm as recommended by guidelines. This one-arm observational study focuses on how personalized timing of surveillance affects outcomes after proctocolectomy with IRAISA or IPAA. During the study, participants will have endoscopic assessments to track the development of advanced neoplasia and characteristics of polyps. Researchers will evaluate the effectiveness and feasibility of different endoscopic removal techniques, the need for additional surgery, surveillance burden, and any complications over up to five years. This long-term monitoring aims to improve personalized care and optimize surveillance strategies for FAP patients post-surgery.

A Personalized Surveillance and Intervention Protocol for Patients With Familial Adenomatous Polyposis That Have Undergone (Procto)Colectomy