What is this study trying to find out about familial adenomatous polyposis (FAP)?

This study is investigating a personalized surveillance plan to monitor and remove polyps in patients with FAP who have had surgery to prevent colorectal cancer. Researchers want to find the best timing for endoscopic check-ups and interventions to stop advanced growths from developing. It is led by the Academisch Medisch Centrum - Universiteit van Amsterdam.

Who may be eligible for this familial adenomatous polyposis clinical trial?

Adults aged 18 or older diagnosed with FAP who have undergone prophylactic (procto)colectomy surgery with IRA, ISA, or IPAA may be eligible. Participants must be able to have all necessary polyps removed endoscopically and not have cancer or require surgery at the start. Please review eligibility criteria for more details.

Is there any cost to participate in this familial adenomatous polyposis clinical trial?

Study-related care, including the surveillance procedures and all trial visits, is provided at no cost. However, personal travel and accommodation expenses may vary and are not guaranteed to be covered by the study.

Actively Recruiting

Age: 18Years +

All Genders

ID04678011

A Personalized Surveillance and Intervention Protocol for Patients With Familial Adenomatous Polyposis That Have Undergone ProctoColectomy

Led by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Updated on 2026-02-23

1000

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

Researchers are evaluating a personalized surveillance and intervention protocol for patients with familial adenomatous polyposis FAP who have undergone prophylactic proctocolectomy. FAP causes numerous polyps in the colon and rectum, leading to nearly certain colorectal cancer if untreated. Surgery such as restorative proctocolectomy or subtotal colectomy is performed to reduce cancer risk, but lifelong monitoring is needed due to the risk of new adenomas developing in remaining tissues. This study aims to provide evidence for tailored endoscopic surveillance intervals to prevent advanced neoplasia by removing lesions early. Participants will follow a personalized endoscopic surveillance schedule with intervals ranging from 6 months to 2 years, based on the severity of their polyposis and endoscopic interventions performed. They will undergo regular endoscopic examinations to monitor and remove polyps larger than 5mm as recommended by guidelines. This one-arm observational study focuses on how personalized timing of surveillance affects outcomes after proctocolectomy with IRAISA or IPAA. During the study, participants will have endoscopic assessments to track the development of advanced neoplasia and characteristics of polyps. Researchers will evaluate the effectiveness and feasibility of different endoscopic removal techniques, the need for additional surgery, surveillance burden, and any complications over up to five years. This long-term monitoring aims to improve personalized care and optimize surveillance strategies for FAP patients post-surgery.

CONDITIONS

Brief Title

A Personalized Surveillance and Intervention Protocol for Patients With Familial Adenomatous Polyposis That Have Undergone (Procto)Colectomy

Who Can Participate

Age: 18Years +

All Genders

Eligibility Criteria

You may qualify if you...

Diagnosis of familial adenomatous polyposis (FAP) confirmed by genetic testing (APC germline mutation) or clinical diagnosis (more than 100 colorectal adenomas with positive family history of FAP)
Have undergone prophylactic (procto)colectomy surgery with ileorectal anastomosis (IRA), ileosigmoidal anastomosis (ISA), or ileal pouch-anal anastomosis (IPAA)
Age 18 years or older

You will not qualify if you...

Unable to remove all polyps that need removal during one or multiple clearing endoscopies
Presence of cancer at baseline endoscopy
Need for surgery at the start of the study

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