Actively Recruiting
Phenotypes, Biomarkers and Pathophysiology in Hereditary Spastic Paraplegias and Related Disorders
Led by Dr. Rebecca Schule · Updated on 2021-05-19
2000
Participants Needed
13
Research Sites
1137 weeks
Total Duration
On this page
Sponsors
D
Dr. Rebecca Schule
Lead Sponsor
G
German Federal Ministry of Education and Research
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of this study is to determine the clinical spectrum and natural progression of Hereditary Spastic Paraplegias (HSP) and related disorders in a prospective multicenter natural history study, identify digital, imaging and molecular biomarkers that can assist in diagnosis and therapy development and study the genetic etiology and molecular mechanisms of these diseases.
CONDITIONS
Official Title
Phenotypes, Biomarkers and Pathophysiology in Hereditary Spastic Paraplegias and Related Disorders
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical or genetic diagnosis of Hereditary Spastic Paraplegia or a related disorder, or
- Unaffected 1st or 2nd degree family member of a primary participant able to give informed consent, or
- Unrelated healthy control able to give informed consent
- Written informed consent
- Willing and able to comply with study procedures
You will not qualify if you...
- Missing informed consent from participant or legal representative
- For controls: evidence of neurodegenerative disease or movement disorders
- Inability to give informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 13 locations
1
University Innsbruck
Innsbruck, Austria, 6020
Actively Recruiting
2
German Center for Neurodegenerative Diseases (DZNE) Bonn
Bonn, Germany, 53127
Actively Recruiting
3
University of Erlangen
Erlangen, Germany, 91054
Actively Recruiting
4
University Medicine Essen
Essen, Germany, 45147
Actively Recruiting
5
University Göttingen
Göttingen, Germany, 37075
Actively Recruiting
6
University Heidelberg
Heidelberg, Germany, 69120
Not Yet Recruiting
7
University of Lübeck
Lübeck, Germany, 23562
Not Yet Recruiting
8
German Center for Neurogedenerative Diseases (DZNE) Magdeburg
Magdeburg, Germany, 39120
Actively Recruiting
9
German Center for Neurodegenerative Diseases (DZNE) München
München, Germany, 80336
Actively Recruiting
10
University of Regensburg
Regensburg, Germany, 93053
Not Yet Recruiting
11
German Center for Neurodegenerative Diseases (DZNE) Rostock
Rostock, Germany, 18147
Not Yet Recruiting
12
University of Tübingen and German Center for Neurodegenerative Diseases (DZNE) Tübingen
Tübingen, Germany, 72076
Actively Recruiting
13
IRCCS Medea Scientific Institute, Conegliano-PIeve di Soligo Research Centre
Pieve di Soligo, Italy, 31053
Not Yet Recruiting
Research Team
R
Rebecca Schüle, PD Dr.
CONTACT
L
Ludger Schöls, Prof. Dr.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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