Actively Recruiting
Physical Fitness and Hot Executive Function in Alzheimer's Risk
Led by National Taiwan Normal University · Updated on 2025-07-23
240
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are examining how physical fitness relates to executive function in older adults aged 50 to 70 over an 18-month period. This observational study aims to find out if improvements in fitness can predict better cognitive performance, focusing on both behavioral and brain activity measures. The study also explores the role of the APOE b54 gene in these fitness-cognition relationships. Participants will undergo assessments at the beginning and end of the 18 months without any exercise program being provided. Fitness tests include cardiorespiratory evaluation using a YMCA submaximal bike test and muscular strength tests for chest and leg presses. Executive function is measured through computer tasks while brain activity is recorded with EEG. Additional data collected include physical activity questionnaires, cognitive screening with the Mini-Mental State Examination (MMSE), memory tests using digit span tasks, and genotyping for APOE b54. During the study, participants complete evaluations lasting about 25 to 30 minutes for each fitness and cognitive test at both time points. Researchers track changes in cardiorespiratory and muscular fitness, cognitive flexibility response time and accuracy, and EEG signals. Secondary measures like global cognition, working memory, physical activity levels, and genetic markers are also assessed. The total participation time spans the baseline and 18-month follow-up assessments.
CONDITIONS
Brief Title
Physical Fitness and Hot Executive Function in Alzheimer's Risk
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 50 to 70 years
- Able to participate in fitness testing
- Normal vision or corrected-to-normal vision
You will not qualify if you...
- Having cardiopulmonary-related diseases
- Having cognitive, neurological, or psychiatric disorders such as dementia, Parkinson's disease, epilepsy, depression, or schizophrenia
- Having infectious diseases like hepatitis, HIV, or Creutzfeldt-Jakob disease
- History of drug or alcohol abuse
- Having color vision deficiency such as color blindness
- Family history of aneurysm
- Taking medications that affect brain function
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants complete comprehensive baseline evaluations assessing physical fitness and executive function.
1 baseline visit (in-person)
Duration - 18 months
Participants are observed over 18 months with no intervention, maintaining their normal daily living conditions.
No visits during this period
Duration - 1 day
Participants complete follow-up assessments evaluating changes in physical fitness and executive function.
1 follow-up visit (in-person)
Trial Site Locations
Total: 1 location
1
National Taiwan Normal University
Taipei, Taiwan
Actively Recruiting
Research Team
C
Chine-Heng Chu, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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