Study on Genetic and Environmental Factors Affecting Pulmonary Fibrosis and Disease Progression in Ireland

What this Trial Is About

Researchers are studying pulmonary fibrosis, a group of lung diseases that cause lung scarring and breathing difficulties. This study focuses on how genes and environmental factors contribute to pulmonary fibrosis development and progression, especially in people with idiopathic pulmonary fibrosis IPF, familial pulmonary fibrosis FPF, and connective tissue disease-related interstitial lung disease CTD-ILD. The goal is to better understand disease behavior and improve early identification of progressive cases. Participants are grouped into three categories those with familial pulmonary fibrosis, those with IPF without family history, and those with CTD-ILD. The study follows 300 patients for one year, monitoring lung function and disease progression using several tests, including spirometry, six-minute walk tests, high-resolution CT scans analyzed by AI, genetic testing, and quality of life questionnaires. Participants also use a home monitoring app to track lung function twice a week. During the study, patients undergo assessments at baseline, six months, and twelve months, including lung function tests, blood tests, exercise capacity evaluations, and questionnaire surveys. Researchers will analyze genetic variants, disease progression, and radiological patterns. The study aims to identify early signs of worsening disease and improve personalized diagnosis and care. Safety and overall health are monitored throughout the one-year follow-up.

Precision Diagnosis and Care for Families With Pulmonary Fibrosis in Ireland