National Study in Denmark on Early First-Trimester Screening to Prevent Preeclampsia in Pregnant Women with Single Babies

What this Trial Is About

Researchers are evaluating a new first-trimester screening program in Denmark to better identify pregnant women at high risk of developing preeclampsia, a condition causing high blood pressure and affecting both mother and babys health. The study aims to see if early detection and preventive treatment with low-dose aspirin can lower the number of women who develop preterm preeclampsia. This observational study is conducted in routine maternity care settings and includes pregnant women with single pregnancies attending first-trimester scans. The screening combines maternal history, blood pressure, ultrasound blood flow measurements, and blood tests to estimate individual risk. Women identified as high risk are offered daily low-dose aspirin until late pregnancy. The program is gradually introduced across hospitals, allowing researchers to compare outcomes before and after implementation while integrating the screening into existing prenatal care workflows without disrupting services. Participants receive information and routine assessments during their first-trimester visit, including blood pressure checks, ultrasound, and blood sampling. Researchers will monitor pregnancy outcomes, aspirin use, and safety through national health records and registries. The study also assesses the screening programs feasibility, acceptability, and safety, with ongoing training and quality checks. The total follow-up extends from the first-trimester assessment through delivery.

Prevention of Preeclampsia in Denmark: A National Implementation Study