Prospective Cohort Study on Anxiety, Depression, and Bipolar Disorder Tracking Clinical and Biological Changes Over Time

What This Trial Is About

Researchers are conducting a prospective observational study to understand how anxiety disorders, depressive disorders, and bipolar disorder evolve over time. The study also aims to identify patterns that could help with earlier recognition, diagnosis, and prediction of future symptoms. It will include about 2,690 participants aged 12 to 55 years from multiple hospitals in China, including people with these disorders and healthy volunteers for comparison. Participants will be followed for 36 months with assessments at baseline and then at 1, 6, 12, 18, 24, 30, and 36 months. The study will collect detailed clinical data, biological samples, brain imaging, brain electrical activity recordings, and digital measurements from wearable devices and tasks involving speech, facial expressions, and eye movements. No treatments are assigned by the study instead, treatments received during routine care will be recorded. During the study, participants will complete regular assessments about symptoms, treatment, daily functioning, and quality of life. Researchers will analyze these data to explore relationships between measurements and symptom changes, treatment outcomes, relapse, and risks of suicide or self-harm. The study will also develop and evaluate artificial intelligence models to aid in diagnosis and prediction of outcomes. Participant involvement includes multiple follow-up visits over three years with various biological and digital assessments.

A Prospective Study of Anxiety, Depression, and Bipolar Disorder in People