Actively Recruiting
Quantifying Motor Network Dynamics to Predict and Enhance Outcomes in Pediatric Dystonia
Led by Children's Hospital Medical Center, Cincinnati · Updated on 2026-01-08
75
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to understand how childhood dystonia, a movement disorder, develops and progresses in children. It focuses on how the brain's motor networks change during motor development and how deep brain stimulation (DBS) affects these networks in children with dystonia. The study will explore neural activity both at rest and during simple motor tasks to gain insights into motor function changes over time. Participants will have noninvasive measurements like EEG and EMG to record brain and muscle activity. Children with DBS will be evaluated both when the device is active and inactive to see how stimulation influences motor network function. This study involves repeated assessments over about two years to track changes in brain activity and connectivity. During the study, participants will undergo neurophysiological tests at different times, including resting and task conditions. The research team will measure changes in motor network activity and brain connectivity using EEG data. Safety and ability to complete the study tasks will be monitored, and the primary outcome is the change in motor network aperiodic activity over time. The total duration includes baseline and follow-up assessments spanning an average of two years.
CONDITIONS
Brief Title
Quantifying Motor Network Dynamics to Predict and Enhance Outcomes in Pediatric Dystonia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of dystonia (with or without DBS) for dystonia subjects
- Willingness and ability to complete study protocols
- Normal developmental milestones for typically developing controls
- No neuropsychiatric disorders for typically developing controls
- No significant medical conditions for typically developing controls
- Age between 6 and 21 years
You will not qualify if you...
- History of epilepsy
- Presence of implanted medical devices except DBS in dystonia subjects
- Lack of cognitive or physical ability to complete study protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Baseline and through study completion, an average of 2 years
Participants with DBS undergo neurophysiological recordings with DBS on and off to assess motor network dynamics.
Multiple visits over 2 years for recordings with DBS on and off
Trial Site Locations
Total: 1 location
1
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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