Actively Recruiting
Observational Study of Oral Lichen Planus Patients: Characteristics, Risk Factors, and Malignant Transformation
Led by Catholic University of the Sacred Heart · Updated on 2026-05-14
300
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Oral Lichen Planus (OLP) is a chronic inflammatory disease mainly affecting the mouth's lining, caused by an immune response that damages the cells in the mouth. This research observes a group of patients with OLP over a long period to check how often their condition changes into oral cancer. It also aims to identify patient characteristics and risk factors linked to this transformation and to assess how well treatments for OLP work. The study looks back at medical records and clinical data of patients with OLP to examine their history and dental health, focusing on factors that may increase the risk of developing oral cancer. It does not involve new treatments but evaluates existing patient information to understand disease progression and treatment effects. Participants will be followed for at least six months, with researchers reviewing their clinical and dental records to gather data. The main measurement is the number of oral cancer cases identified from January 2024 to January 2028. This observational approach helps monitor long-term outcomes and characteristics without active intervention, with the study concluding in January 2029.
CONDITIONS
Brief Title
Rate of Malignant Transformation and Clinical Characteristics Among an Oral Lichen Planus Cohort: a Retrospective Center Experience
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical-histological diagnosis of Oral lichen planus
- Patients who gave consensus to personal data treatment
- Minimum 6 months follow-up
You will not qualify if you...
- Patients who did not give consensus to personal data treatment
- Oral lichenoid lesions
- Patients with anamnesis of hematopoietic stem cells transplant
- Patients with a OSCC at the first histological examination (including OSCC patients with OLP background)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 4 years
Participants who have been diagnosed with Oral Lichen Planus are observed retrospectively to assess clinical characteristics, risk factors, and rate of malignant transformation over time.
Trial Site Locations
Total: 1 location
1
Catholic University of the Sacred Heart
Roma, Italy, 00168
Actively Recruiting
Research Team
C
Carlo Lajolo Associate Professor, DDS, MD, PhD
C
Carlo Lajolo Associate Professor, MD, DDS, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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