Actively Recruiting

Age: 45Years +
All Genders
ID06958302

The Relation Between Diabetic Neuropathy and Muscle Mass in Type 2 Diabetes Mellitus Patients

Led by Ain Shams University · Updated on 2025-05-06

60

Participants Needed

2

Research Sites

31 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This research aims to explore the connection between diabetic neuropathy and muscle mass in patients with type 2 diabetes mellitus who are aged 45 years or older. The study focuses on understanding how diabetic nerve damage relates to muscle loss and weakness, which may contribute to sarcopenia, a condition involving reduced muscle mass and function. The research involves patients with type 2 diabetes to assess this important health relationship. Participants will undergo several assessments to measure muscle mass and function. Ultrasound will be used to measure the thickness of the anterior thigh muscle and adjust it according to body mass index to estimate muscle mass. Clinical tests like hand grip strength and chair stand tests will evaluate muscle power. Nerve conduction studies will assess diabetic neuropathy in the lower limbs. These tests are scheduled over three weeks: neurological exams and performance tests on day 1, nerve studies two weeks later, and muscle ultrasound in the third week. During the study, participants will have neurological and physical performance assessments, nerve conduction studies, and ultrasound imaging to measure muscle thickness. Researchers will evaluate sarcopenia by combining muscle mass and function data and analyze its relationship with diabetic neuropathy. The study period includes these assessments over a few weeks, with careful monitoring of muscle and nerve health. Participation involves attending these evaluations as scheduled to help researchers understand the link between muscle health and diabetic nerve damage.

CONDITIONS

Brief Title

The Relation Between Diabetic Neuropathy and Muscle Mass in Type 2 Diabetes Mellitus Patients

Who Can Participate

Age: 45Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients diagnosed with type 2 diabetes mellitus
  • Age 45 years or older
Not Eligible

You will not qualify if you...

  • Type 1 diabetes mellitus or gestational diabetes mellitus
  • Severe cardiopulmonary disease
  • Significant or previous neurological disorders causing daily activity difficulties (e.g., ischemic stroke, Parkinson disease)
  • Visual deficits or psychiatric problems
  • Other neuropathy-related factors such as alcohol use, nutritional issues, poisoning, or drug addiction
  • Renal diseases, malignancy, or autoimmune diseases
  • Long-term use of steroids

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

Diagnostic Evaluation

Duration - 3 weeks

Participants undergo neurological examination, clinical physical performance tests, nerve conduction studies, and ultrasound assessments to evaluate diabetic neuropathy and muscle mass.

3 visits over 3 weeks

Trial Site Locations

Total: 2 locations

1

Ain Shams university

Cairo, Abbassia, Egypt, 00202

Actively Recruiting

2

Ain Shams university

Cairo, Abbassia, Egypt, 00202

Actively Recruiting

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Research Team

W

Wafaa M Mohamed Abd ElAzim, Masters degree

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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Published Research Related To This Trial

Test-Retest Reliability of Measurements of Hand-Grip Strength Obtained by Dynamometry from Older Adults: A Systematic Review of Research in the PubMed Database.

R W Bohannon

https://pubmed.ncbi.nlm.nih.gov/28555708

Association of Muscle Strength and Gait Speed with Cross-Sectional Muscle Area Determined by Mid-Thigh Computed Tomography - A Comparison with Skeletal Muscle Mass Measured by Dual-Energy X-Ray Absorptiometry.

K Tsukasaki, Y Matsui, H Arai...

https://pubmed.ncbi.nlm.nih.gov/32259181

Regional and total muscle mass, muscle strength and physical performance: The potential use of ultrasound imaging for sarcopenia.

Ayşe Merve Ata, Murat Kara, Bayram Kaymak...

https://pubmed.ncbi.nlm.nih.gov/30953961