Actively Recruiting
REmimazolam vs Propofol Total Intravenous Anesthesia on Outcomes After Major Noncardiac SurgEry
Led by Nanfang Hospital, Southern Medical University · Updated on 2025-08-26
7188
Participants Needed
44
Research Sites
247 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this randomized controlled trial is to compare total intravenous anesthesia with remimazolam vs total intravenous anesthesia with propofol in moderate-to-high risk patients undergoing major elective noncardiac surgery under general anesthesia. The primary hypothesis is that total intravenous anesthesia with remimazolam can increase days alive and out of hospital at postoperative day 30 compared with total intravenous anesthesia with propofol.
CONDITIONS
Official Title
REmimazolam vs Propofol Total Intravenous Anesthesia on Outcomes After Major Noncardiac SurgEry
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 65 years
- Undergoing elective major surgery under general anesthesia with expected surgery time over 2 hours and postoperative stay longer than 2 days
- Meets at least one of the following: history of coronary artery disease, stroke, congestive heart failure, preoperative NT-proBNP >200 pg/mL or BNP >92 pg/mL, age 70 years, diabetes requiring medical treatment, ASA status 3 or 4, chronic kidney disease with preoperative serum creatinine >133 bcmol/L or 1.5 mg/dL, peripheral arterial disease, preoperative serum albumin <30 g/L, or preoperative hemoglobin <100 g/L
You will not qualify if you...
- Undergoing organ transplantation, cardiac, craniocerebral, burn, or interventional operations
- Scheduled for low risk or minor surgery
- End-stage renal disease requiring renal-replacement therapy
- Hepatic dysfunction classified as Child B or C
- Previous liver or kidney transplantation
- Allergic to general anesthetics
- Unable to receive bispectral index monitoring
- ASA score of 5 or higher
- Received general anesthesia within 30 days before or expected to have general anesthesia within 30 days after surgery
- Need for prolonged airway protection or mechanical ventilation after surgery
- Currently participating in another interventional study
- Previously participated in this study
- Pregnant or breastfeeding women
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 44 locations
1
The First Affiliated Hospital of Anhui Medical University
Hefei, Anhui, China, 230022
Actively Recruiting
2
Huainanchaoyang Hospital
Huainan, Anhui, China
Actively Recruiting
3
Suzhou First People's Hospital
Suzhou, Anhui, China
Actively Recruiting
4
Beijing Chaoyang Hospital, Capital Medical University
Beijing, Beijing Municipality, China, 100016
Actively Recruiting
5
Xinqiao Hospital of Chongqing
Chongqing, Chongqing Municipality, China, 400037
Actively Recruiting
6
The First People's Hospital of Foshan
Foshan, Guangdong, China
Actively Recruiting
7
Southern Medical University Zhujiang Hospital
Guangzhou, Guangdong, China, 510260
Actively Recruiting
8
Southern Medical University Nanfang Hospital
Guangzhou, Guangdong, China, 510515
Actively Recruiting
9
Zhongshan City People's Hospital
Zhongshan, Guangdong, China
Actively Recruiting
10
The Affiliated Hospital of Guizhou Medical University
Guiyang, Guizhou, China, 550001
Actively Recruiting
11
Qiandongnanzhou People's Hospital
Kaili, Guizhou, China
Actively Recruiting
12
The Fourth Hospital of Hebei Medical University
Shijiazhuang, Hebei, China, 050000
Actively Recruiting
13
The First Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
Actively Recruiting
14
Kaifeng Central Hospital
Kaifeng, Henan, China
Actively Recruiting
15
The 989 Hospital of the People's Liberation Army Joint Support Force
Pingdingshan, Henan, China
Actively Recruiting
16
Shangqiu Third People's Hospital
Shangqiu, Henan, China
Actively Recruiting
17
Changge people's hospital
Xuchang, Henan, China
Actively Recruiting
18
Henan Provincial People's Hospital
Zhengzhou, Henan, China, 450003
Actively Recruiting
19
Henan Province Hospital of TCM
Zhengzhou, Henan, China
Actively Recruiting
20
The Second Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China
Actively Recruiting
21
Wuhan University People's Hospital
Wuhan, Hubei, China, 430060
Actively Recruiting
22
The Central Hospital of Wuhan
Wuhan, Hubei, China
Actively Recruiting
23
Hunan Provincial People's Hospital
Changsha, Hunan, China, 410002
Actively Recruiting
24
Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University)
Changsha, Hunan, China
Actively Recruiting
25
The First Affiliated Hospital Of University Of South China
Hengyang, Hunan, China
Actively Recruiting
26
The First Affiliated Hospital of Baotou Medical College
Baotou, Inner Mongolia, China
Actively Recruiting
27
The Second Affiliated Hospital of Baotou Medical College
Baotou, Inner Mongolia, China
Actively Recruiting
28
The Second Affiliated Hospital of Inner Mongolia Medical University
Hohhot, Inner Mongolia, China
Actively Recruiting
29
Jiangsu Provincial People's Hospital
Nanjing, Jiangsu, China, 210029
Actively Recruiting
30
The Second Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China, 330008
Actively Recruiting
31
General Hospital of Northern Theater Command
Shenyang, Liaoning, China, 110016
Actively Recruiting
32
The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital
Jinan, Shandong, China
Actively Recruiting
33
The 960th Hospital of the PLA Joint Logistic Support Force
Zibo, Shandong, China
Actively Recruiting
34
Bao Ji City People's Hospital（BaoJi Emergency Medical Center）
Baoji, Shanxi, China
Actively Recruiting
35
Fenyang Hospital of Shanxi Province
Fenyang, Shanxi, China
Actively Recruiting
36
The First Hospital of Shanxi Medical University
Taiyuan, Shanxi, China, 030001
Actively Recruiting
37
Shanxi Provincial People's Hospital
Taiyuan, Shanxi, China
Actively Recruiting
38
Sichuan Provincial People's Hospital
Chengdu, Sichuan, China, 610072
Actively Recruiting
39
The First Affiliated Hospital of Xinjiang Medical University
Ürümqi, Xinjiang, China
Actively Recruiting
40
The First People's Hospital of Yunnan Province
Kunming, Yunnan, China, 650028
Actively Recruiting
41
The First Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, China, 650032
Actively Recruiting
42
The First Affiliated Hospital of Ningbo University
Ningbo, Zhejiang, China
Actively Recruiting
43
Chongqing Western Hospital
Chongqing, China
Actively Recruiting
44
Liangjiang Hospital of Chongqing Medical University
Chongqing, China
Actively Recruiting
Research Team
B
Bingcheng Zhao, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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