Evaluation of Respiratory and Limb Muscle Function and Physical Performance in Adults Undergoing Lung Transplant Surgery

What this Trial Is About

This observational study focuses on adults who are awaiting lung transplantation and aims to evaluate the properties of their respiratory and limb muscles. The study investigates how muscle weakness and dysfunction may relate to physical performance, symptoms such as frailty and fatigue, and recovery after lung transplant surgery. Researchers seek to better understand the specific role these muscle impairments play in lung transplant candidates, as this is not well defined. Participants will undergo a series of assessments including ultrasound imaging of the diaphragm, abdominal, and quadriceps muscles, as well as respiratory and limb strength testing. These evaluations will occur weekly from hospital admission through postoperative day 14. Physical performance tests and symptom questionnaires will be administered before and after transplantation. Medical records will also be reviewed to collect information on ICU stay, hospital length of stay, rehabilitation, and recovery outcomes. During the study, participants will have muscle ultrasounds at weekly intervals and strength and functional tests at baseline and postoperative day 14. Patient-reported symptoms such as dyspnea, pain, fatigue, and anxiety will be assessed alongside physical performance and frailty status. The research team will monitor recovery progress through clinical data and functional measurements, aiming to correlate muscle function with postoperative mobility and discharge status. The total participation spans from hospital admission to about two weeks after surgery, with additional follow-up through hospital discharge.

Respiratory, Limb Muscle Properties, and Physical Performance in Adult Lung Transplant Recipients