Study Evaluating Risk Factors for Primary Graft Dysfunction After Lung or Heart-Lung Transplantation

What this Trial Is About

Primary graft dysfunction PGD is a serious lung complication that can happen within days after lung transplant surgery, affecting up to 25% of patients. It involves fluid buildup in the lungs and low oxygen levels, often leading to costly treatments and being a leading cause of death post-transplant. This study aims to find out if high levels of certain chemicals in the blood increase the risk of developing PGD after lung or heart-lung transplantation. Participants will have blood samples taken before surgery, immediately after surgery, and 24 hours post-surgery to measure chemicals related to bleeding, clotting, and oxidative stress. Researchers will also review medical records to understand risk factors better. There are no extra study visits required beyond these sample collections and record reviews. During the study, participants blood samples and medical records will be analyzed to track the development of PGD within 72 hours after transplantation, based on established criteria. This study relies on existing clinical care and does not involve additional treatments or interventions. The total participation involves only the sample collections around the surgery and review of medical information, with no extra follow-up visits.

Risk Factors That Increase the Chance of Developing Primary Graft Dysfunction After Lung Transplantation