Clinical Risk Factors for Primary Graft Dysfunction After Lung or Heart-Lung Transplantation

What this Trial Is About

Primary graft dysfunction (PGD) is a serious lung problem that can happen within days after lung transplant surgery. This condition affects up to 25% of lung transplant patients and involves fluid buildup in the lungs and low oxygen levels in the blood. PGD is the leading cause of death after lung transplantation and often leads to high treatment costs. The study aims to find out if high levels of certain chemicals in the blood are linked to a greater risk of developing PGD after a lung transplant. The study will enroll people undergoing lung or combined heart and lung transplants. Blood samples will be taken before surgery, right after surgery, and 24 hours later to measure levels of chemicals related to bleeding, clotting, and cell damage. Researchers will also review participants' medical records. There are no extra study visits required beyond the scheduled transplant care. Participants will be monitored mainly by analyzing blood samples and medical records to check for PGD within 72 hours after transplantation, based on established criteria. There is no intervention or treatment being tested, as this is an observational study focused on identifying risk factors. The study will last through the transplant period with no additional visits, and safety will be monitored through routine clinical care.

Risk Factors That Increase the Chance of Developing Primary Graft Dysfunction After Lung Transplantation