Actively Recruiting

Phase Not Applicable
Age: 18Years - 64Years
All Genders
ID07065318

Comparison of Continuous Aerobic Exercise and High-Intensity Interval Training Effects on ICF Assessments in Lung Transplant Candidates

Led by Ankara City Hospital Bilkent · Updated on 2025-07-15

34

Participants Needed

1

Research Sites

N/A

Total Duration

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AI-Summary

What this Trial Is About

This research focuses on lung transplant candidates with interstitial lung disease (ILD), aiming to study the effects of two different exercise programs on their physical function and health status. The trial compares high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) to assess their impact on exercise capacity, body structure and function, and activity and participation levels. The study is designed as a randomized controlled trial to better understand rehabilitation options before lung transplantation. Participants will be randomly assigned to one of two exercise groups. The first group will perform HIIT involving 30-second high-intensity intervals at 85-100% of maximum workload alternated with 30 seconds at 40% workload, completing 20 such cycles with warm-up and cool-down periods. The second group will engage in continuous moderate-intensity exercise at 60-80% of maximum workload for 20 to 30 minutes. All exercise sessions will use an electronically calibrated ergometer cycle, and the training duration for both groups is planned for 8 weeks. Throughout the study, participants will undergo various assessments before and after the exercise program, including the 6-minute walk test to measure exercise capacity, pulmonary function tests, and evaluations of comorbidities, daily living activities, and quality of life. Additional measurements will assess muscle strength, frailty, respiratory muscle endurance, and psychological factors like fear of movement. Researchers will monitor these outcomes over roughly one year to understand how the exercise programs influence participants' health and readiness for lung transplantation.

CONDITIONS

Brief Title

Lung Transplant Candidates: Effects of Aerobic vs. HIIT Training on ICF Assessments

Who Can Participate

Age: 18Years - 64Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Diagnosed with interstitial lung disease and followed at Ankara City Hospital Chest Diseases Clinic
  • Aged 18 years or older
  • Diagnosed with ILD according to the ATS/ERS 2022 international guideline
  • On the lung transplant waiting list and evaluated for listing by chest diseases department
  • Willing and able to participate regularly in the exercise program
  • Dyspnea level of 2 or higher on the Modified Medical Research Council scale and able to walk
  • Receiving long-term oxygen support included
Not Eligible

You will not qualify if you...

  • History of exertional syncope
  • Currently experiencing acute exacerbation
  • Diagnosis of sarcoidosis
  • Serious musculoskeletal, neurological, or cardiovascular problems limiting exercise
  • Aortic aneurysm larger than 5.5 cm
  • Cardiovascular issues preventing exercise during cardiological evaluation prior to pulmonary rehabilitation

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - 8 weeks

Participants engage in assigned exercise programs, either high-intensity interval training or moderate-intensity continuous training, to assess effects on lung function and physical capacity.

Exercise sessions multiple times per week using an ergometer cycle

Follow-up

Duration - Up to approximately 1 year

Participants are monitored for changes in exercise capacity, respiratory function, frailty, and quality of life after completing the exercise program.

Regular assessments during follow-up visits

Trial Site Locations

Total: 1 location

1

Ankara Bilkent City Hospital

Ankara, Ankara, Turkey (Türkiye), 06000

Actively Recruiting

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Research Team

U

Ulas A Ar, MSc

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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