Actively Recruiting
Long-term Risk of Recurrent Cervical Artery Dissection After Pregnancy (LONG-RECAP Study)
Led by University Hospital, Basel, Switzerland · Updated on 2024-12-13
1000
Participants Needed
12
Research Sites
30 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating whether pregnancy increases the risk of recurrent cervical artery dissection (CeAD) and delayed stroke in women who have had a prior CeAD. This observational, multicenter case-control study collects long-term data from several stroke centers to better understand the relationship between pregnancy and CeAD recurrence. They also explore if delivery method influences recurrence and whether women chose to avoid future pregnancies due to the initial CeAD. The study compares two groups of women: those who became pregnant at least once after their first CeAD and those who did not become pregnant afterward. Data is gathered through medical record reviews and patient interviews, covering long-term follow-up of at least six months with no upper time limit. Outcomes include recurrent CeAD, ischemic or hemorrhagic stroke, death, and functional status measured by the modified Rankin Scale. Participants provide information about pregnancy history and health outcomes during follow-up visits. Researchers assess the occurrence of recurrent CeAD, strokes, and death over periods up to 35 years from the initial event. They use statistical analysis to compare risks between women who became pregnant and those who did not. The study lasts until July 2025 and monitors functional outcomes as well as survival over the long term.
CONDITIONS
Brief Title
Risk of Recurrent CeAD After Pregnancy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female
- Prior symptomatic cervical artery dissection (index CeAD)
- At least one long-term follow-up visit at least 6 months after the initial event
- Available information on recurrent dissection, ischemic stroke, hemorrhagic stroke, and functional outcome by mRS
- Data on pregnancy after the initial event
- At least 18 years old at the initial event
You will not qualify if you...
- Male patients
- Age under 18 years
- No long-term follow-up or follow-up less than 6 months after initial event
- No pregnancy data available after initial event
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 35 years
Participants with prior cervical artery dissection are observed over many years to track the occurrence of recurrent CeAD, stroke, or death and assess functional outcomes.
Follow-up visits at least once after 6 months and periodically thereafter
Trial Site Locations
Total: 12 locations
1
University of Utah
Salt Lake City, Utah, United States, 84112
Actively Recruiting
2
University of Virginia
Charlottesville, Virginia, United States, 22908
Actively Recruiting
3
Stroke Unit Sanatorio Allende
Córdoba, Argentina, X5000BFB
Actively Recruiting
4
Department of Neurology, Medical University of Innsbruck
Innsbruck, Tyrol, Austria, 6020
Actively Recruiting
5
Helsinki University Central Hospital
Helsinki, Finland
Actively Recruiting
6
Charité Universitätsmedizin, Centrum für Schlaganfallforschung
Berlin, Germany, 10117
Actively Recruiting
7
Neurologische Klinik und Poliklinik, LMU Klinikum Campus Großhadern
Munich, Germany, 81377
Actively Recruiting
8
Hadassah-Hebrew University Medical Center
Jerusalem, Israel, 91120
Actively Recruiting
9
Neurology Clinic, University of Brescia
Brescia, Italy
Actively Recruiting
10
Stroke Clinic, National Institute of Neurology and Neurosurgery Manuel Velasco Suárez
Mexico City, Mexico, 14269
Actively Recruiting
11
University Hospital Basel, Stroke Center
Basel, Switzerland, 4031
Actively Recruiting
12
University Hospital Zurich, Stroke Center
Zurich, Switzerland
Actively Recruiting
Research Team
S
Stefan T Engelter, MD
S
Sandro K Fischer
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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