Study of Endomyocardial Biopsy and Cause-Based Treatment in Children and Teens With Inflammatory Heart Disease and Arrhythmias An Integrated Approach to Diagnosis and Treatment

What this Trial Is About

This research focuses on myocarditis, an inflammatory heart disease often caused by viral infections, autoimmune reactions, or toxic agents. Myocarditis can present with a variety of symptoms including chest pain, heart failure, and various irregular heart rhythms. The conditions outcome can range from mild and self-limiting to severe forms leading to chronic heart problems or sudden adverse events. The study aims to enhance understanding and management of myocarditis, especially its arrhythmic forms, by comparing diagnostic and therapeutic strategies across different patient groups. The study is observational, both retrospective and prospective, and involves multiple centers. It compares invasive endomyocardial biopsy with noninvasive imaging techniques such as cardiac magnetic resonance, CT scans, and PET scans. Patients receive diagnostic and treatment plans tailored to their condition, including support treatments, cardiac medications, device implants, and arrhythmia ablation when needed. Patients with arrhythmias are categorized into groups based on the type and severity of their arrhythmia, and specific management plans are applied accordingly. Participants provide data through clinical assessments including blood tests, electrocardiograms, imaging, and continuous heart monitoring. The study tracks major and minor cardiac events, diagnostic accuracy, biomarker levels, arrhythmia characteristics, and treatment responses over time, with follow-ups extending up to 10 years. Monitoring includes reassessment for disease progression or healing and evaluation of arrhythmia interventions. The goal is to develop optimal diagnostic and therapeutic approaches for pediatric patients with myocarditis and related arrhythmias.

Role of Endomyocardial Biopsy and Aetiology-based Treatment in Pediatric Patients with Inflammatory Heart Disease in Arrhythmic and Non-arrhythmic Clinical Presentations: an Integrated Approach for the Optimal Diagnostic and Therapeutic Management (MYOPED)