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The Role of Wolters Pulpitis Classification, Apical Periodontitis, and Artificial Intelligence-Assisted Diagnosis in Predicting the Success of Full Pulpotomy in Symptomatic Permanent Mature Molars: A Randomized Controlled Trial
Led by Misr International University · Updated on 2026-01-21
58
Participants Needed
2
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating how certain factors like the severity of pulpal inflammation, carious pulp exposure, and apical periodontitis affect the success of full pulpotomy in mature permanent molars diagnosed with irreversible pulpitis. The study also explores how artificial intelligence (AI) can assist in predicting the treatment outcome using pre-operative X-rays. This is a randomized controlled trial conducted by Misr International University to compare treatments and diagnostic methods. Participants will be randomly assigned to receive either full pulpotomy or conventional root canal treatment, the standard care for irreversible pulpitis. Full pulpotomy involves removing caries, preparing the access cavity, achieving hemostasis, applying bioceramic material, and sealing the cavity with a glass ionomer restoration. Both groups will be monitored with clinical and radiographic evaluations at 1, 3, and 6 months after treatment. The AI software will analyze pre-operative X-rays to detect carious pulp exposure and apical periodontitis, and its diagnostic accuracy will be compared to clinical findings. During the study, patients will have pre-operative assessments including pulp status classification and digital radiographs to evaluate caries depth and apical periodontitis. Follow-up visits at 1, 3, and 6 months will assess the percentage of successful cases based on clinical and radiographic criteria. The AI's sensitivity and specificity in detecting pulp exposure will also be measured on the day of the procedure. This study lasts at least 6 months after treatment and includes safety monitoring through regular follow-ups.
CONDITIONS
Brief Title
The Role of the Pre-operative Condition and Artificial Intelligence-Assisted Diagnosis in Predicting the Success of Full Pulpotomy in Symptomatic Permanent Mature Molars
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Mature permanent molars with irreversible pulpitis
- Presence of bleeding from all canals
- The tooth is not periodontally compromised
You will not qualify if you...
- Non-vital teeth
- Uncontrolled bleeding from any of the canals after ten minutes of application of hemostatic agent
- Molars with immature roots
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Single treatment visit
Participants receive either full pulpotomy or conventional root canal treatment for irreversible pulpitis in mature permanent molars.
1 treatment visit (in-person)
Duration - 6 months
Participants are followed up to assess clinical and radiographic success after treatment.
Visits at 1, 3, and 6 months post-treatment
Trial Site Locations
Total: 2 locations
1
Misr International University (MIU)
Cairo, Egypt
Actively Recruiting
2
Misr International University
Cairo, Egypt
Actively Recruiting
Research Team
M
Mayand A Amer, B.D.S.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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