Studying the Effectiveness of SBRT and Surgery for Spinal Cord Compression from Solid Tumor Metastases

What this Trial Is About

Researchers are evaluating the use of Stereotactic Body Radiotherapy SBRT in managing epidural spinal metastases from solid tumors. This observational study aims to document neurological outcomes, physical performance, and quality of life after surgery combined with SBRT for patients with imminent or actual spinal cord compression. These results will be compared with historical data from patients treated with surgery and conventional radiotherapy between 2011 and 2019 at UZLeuven. Participants will undergo surgery followed by SBRT as part of their treatment for spinal metastases. If surgery is not possible due to contraindications, patients may receive SBRT alone and still be included in the study. The study tracks neurological function and quality of life using standardized assessments at multiple time points before surgery, shortly after surgery, and during follow-up visits for up to five years. Participants will complete neurological evaluations including Frankel scores, Karnofsky scores, and urinary sphincter control assessments before surgery, two weeks after surgery, every three months for one year, and yearly up to five years or until death. Quality of life is also assessed using the EQ5D3L questionnaire following the same schedule. The study involves long-term monitoring to understand the effects of SBRT combined with surgery or alone on patient outcomes.

SBRT in the Management of Solid Spinal Metastases