Study on How Sex Hormones Affect Weight Loss Benefits of Calorie Restriction in Different Ages and Genders

What this Trial Is About

Researchers are investigating how sex hormones influence the effects of calorie restriction on obesity, with a focus on age- and sex-related differences. The study aims to better understand how men and women, especially women around menopause, respond differently to dieting and fat loss. This research involves healthy overweight or obese adults and seeks to improve public health guidance for managing weight and promoting healthy aging. Participants will undergo two phases first, a 3-day maintenance diet tailored to their energy needs, followed by a 6-week calorie-restricted high-protein diet designed to reduce calorie intake gradually. The study includes groups of younger and older men and women, including menopausal women with and without hormone replacement therapy. Body composition and energy expenditure will be closely monitored using advanced techniques, and blood and fat tissue samples will be collected to study hormone effects. During the 53-day study period, participants will have frequent assessments including weight measurements three times a week, energy expenditure tracking, and blood tests at multiple time points. Researchers will measure changes in body mass, metabolic rate, body fat percentage, hormone concentrations, and other metabolic markers. The study also monitors bone mineral content and body water levels. This comprehensive approach aims to clarify how calorie restriction affects weight loss and metabolism across different age and sex groups.

Sex Hormones as Regulators of the Age- and Sex-dependent Benefits of Caloric Restriction