Single-Cell Sequencing Analysis of Radiation Pneumonitis Signals in Patients Treated for Cancer with Radiotherapy

What this Trial Is About

Researchers are investigating radiation pneumonitis, a serious lung inflammation caused by radiotherapy in cancer treatment, particularly in lung cancer patients. This condition can lead to severe breathing problems and even death, and current treatment options are limited. The study aims to better understand the cellular mechanisms behind radiation pneumonitis using a new technique called single-cell RNA sequencing, which can identify different cell types and their activity in affected lung tissue. Participants who have received thoracic radiotherapy and show signs of radiation pneumonitis will undergo a clinical bronchoscopy as part of the ELFMAN study, where a sample of lung cells will be collected. This sample will be analyzed using single-cell sequencing to identify the cells present and their functions. The procedure involves deep bronchial brushings to safely obtain cells for analysis while minimizing risk. The study will recruit patients over a year, aiming to create a detailed dataset within a month of sample collection. During the study, participants will be assessed for lung inflammation signs and must be stable enough to tolerate bronchoscopy without oxygen support. Researchers will monitor the success of the sequencing process and look for specific signals related to radiation pneumonitis over several months. The study may help identify new targets for treatment, improving the management of this lung toxicity in cancer patients. Participation involves bronchoscopy and follow-up evaluations to understand lung cell behavior after radiotherapy.

Single-Cell Sequencing Analysis of Radiation Pneumonitis Signals In Patients Treated For Cancer With Radiotherapy