Actively Recruiting
Single-Cell Sequencing Analysis of Radiation Pneumonitis Signals In Patients Treated For Cancer With Radiotherapy
Led by NHS Lothian · Updated on 2026-01-09
5
Participants Needed
3
Research Sites
109 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patients with signs of radiation induced lung inflammation, who are referred for a clinical bronchoscopy for investigation, will have a sample sent for single cell sequencing. This is a novel technique which allows for identification of which cells are present and what they are doing. This hopes to better understand radiation pneumonitis, a dose-limiting toxicity in cancer treatment which can be highly morbid and even fatal.
CONDITIONS
Official Title
Single-Cell Sequencing Analysis of Radiation Pneumonitis Signals In Patients Treated For Cancer With Radiotherapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age over 18 years
- Received thoracic radiotherapy
- Clinical or radiological signs consistent with Radiation Pneumonitis occurring 1 to 4 months after radiotherapy, including breathlessness (especially with exertion), cough, or chest discomfort
- Ambulatory and oxygen independent with oxygen saturation above 92% on room air
- Hemodynamically stable and able to tolerate and consent to bronchoscopy and related study procedures
You will not qualify if you...
- Contraindications to bronchoscopy such as previous intolerance, inability to lie flat, or oxygen saturation below 92% on room air
- Requires hospital admission or is oxygen dependent
- Tested positive for Covid-19 within 6 weeks before enrollment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Centre for Information Research, University of Edinburgh
Edinburgh, United Kingdom, EH16 4UU
Not Yet Recruiting
2
Henderson Lab
Edinburgh, United Kingdom, EH16 4UU
Not Yet Recruiting
3
Edinburgh Cancer Centre
Edinburgh, United Kingdom, EH4 2XU
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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