Actively Recruiting
Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases
Led by Canadian Cancer Trials Group · Updated on 2026-05-12
206
Participants Needed
86
Research Sites
475 weeks
Total Duration
On this page
Sponsors
C
Canadian Cancer Trials Group
Lead Sponsor
A
Alliance for Clinical Trials in Oncology
Collaborating Sponsor
AI-Summary
What this Trial Is About
Stereotactic radiosurgery (SRS) is a commonly used treatment for brain tumors. It is a one-day (or in some cases two day), out-patient procedure during which a high dose of radiation is delivered to small spots in the brain while excluding the surrounding normal brain. Whole brain radiation therapy with hippocampal avoidance (HA-WBRT) is when radiation therapy is given to the whole brain, while trying to decrease the amount of radiation that is delivered to the area of the hippocampus. The hippocampus is a brain structure that is important for memory. Memantine is a drug that is given to help relieve symptoms that can be caused by WBRT, including problems with memory and other mental symptoms. Health Canada, the regulatory body that oversees the use of drugs in Canada, has not approved the sale or use of memantine in combination with WBRT to treat this kind of cancer, although they have allowed its use in this study.
CONDITIONS
Official Title
Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients must have 5 to 15 brain metastases counted on an MRI within 30 days before randomization
- Patients must have a diagnosed non-hematopoietic malignancy confirmed by cytology or histology
- The largest brain metastasis must be smaller than 2.5 cm in diameter
- The treatment center must have Gamma Knife, Cyberknife, or linear accelerator radiosurgery capabilities
- Patients must be 18 years of age or older
- Patients must be able and willing to complete quality of life questionnaires in English or French
- ECOG performance status must be 0, 1, or 2
- Creatinine clearance must be at least 30 ml/min within 28 days before registration
- Neurocognitive testing must be performed by a credentialed examiner
- The treatment facility must be credentialed to perform SRS and HA-WBRT
- Patients must provide informed consent according to local regulations
- Patients must be available for treatment and follow-up
- Treatment must begin within 14 days of enrollment
- Women and men of childbearing potential must agree to use effective contraception
You will not qualify if you...
- Pregnant or nursing women
- Men or women of childbearing potential unwilling to use adequate contraception
- Inability to complete a brain MRI
- Known allergy to gadolinium
- Prior cranial radiation therapy
- Planned cytotoxic chemotherapy within 48 hours before or after SRS or HA-WBRT
- Diagnosis of primary germ cell tumor, small cell carcinoma, or lymphoma
- Widespread leptomeningeal metastasis or involvement of cranial nerves or cerebrospinal fluid
- Brain metastasis within 5 mm of the optic chiasm or optic nerves
- Surgical resection of brain metastasis (stereotactic biopsies allowed)
- More than 15 brain metastases on volumetric MRI or more than 10 on non-volumetric MRI
- Prior allergic reaction to memantine
- Current alcohol or drug abuse
- Current use of NMDA antagonists like amantadine, ketamine, or dextromethorphan
- Diagnosis of chronic liver disease or cirrhosis (Child-Pugh class B or C)
- Brain ventricular system distortion making hippocampal delineation difficult
AI-Screening
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Trial Site Locations
Total: 86 locations
1
University of Arizona Cancer Center-Orange Grove Campus
Tucson, Arizona, United States, 85704
Actively Recruiting
2
University of Arizona Cancer Center-North Campus
Tucson, Arizona, United States, 85719
Actively Recruiting
3
City of Hope Corona
Corona, California, United States, 92882
Actively Recruiting
4
City of Hope Comprehensive Cancer Center
Duarte, California, United States, 91010
Actively Recruiting
5
City of Hope at Irvine Lennar
Irvine, California, United States, 92618
Actively Recruiting
6
UC San Diego Moores Cancer Center
La Jolla, California, United States, 92093
Suspended
7
City of Hope Antelope Valley
Lancaster, California, United States, 93534
Actively Recruiting
8
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California, United States, 92868
Active, Not Recruiting
9
Kaiser Permanente-Rancho Cordova Cancer Center
Rancho Cordova, California, United States, 95670
Active, Not Recruiting
10
Rohnert Park Cancer Center
Rohnert Park, California, United States, 94928
Active, Not Recruiting
11
The Permanente Medical Group-Roseville Radiation Oncology
Roseville, California, United States, 95678
Active, Not Recruiting
12
South Sacramento Cancer Center
Sacramento, California, United States, 95823
Active, Not Recruiting
13
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, United States, 95051
Active, Not Recruiting
14
City of Hope South Pasadena
South Pasadena, California, United States, 91030
Actively Recruiting
15
Kaiser Permanente Cancer Treatment Center
South San Francisco, California, United States, 94080
Active, Not Recruiting
16
City of Hope South Bay
Torrance, California, United States, 90503
Actively Recruiting
17
City of Hope Upland
Upland, California, United States, 91786
Actively Recruiting
18
Boca Raton Regional Hospital
Boca Raton, Florida, United States, 33486
Active, Not Recruiting
19
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida, United States, 33146
Actively Recruiting
20
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida, United States, 33442
Actively Recruiting
21
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood, Florida, United States, 33021
Active, Not Recruiting
22
Mayo Clinic in Florida
Jacksonville, Florida, United States, 32224-9980
Active, Not Recruiting
23
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, United States, 33136
Actively Recruiting
24
Memorial Hospital West
Pembroke Pines, Florida, United States, 33028
Active, Not Recruiting
25
UM Sylvester Comprehensive Cancer Center at Plantation
Plantation, Florida, United States, 33324
Actively Recruiting
26
Moffitt Cancer Center
Tampa, Florida, United States, 33612
Active, Not Recruiting
27
Piedmont Hospital
Atlanta, Georgia, United States, 30309
Active, Not Recruiting
28
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, United States, 30322
Suspended
29
Emory Saint Joseph's Hospital
Atlanta, Georgia, United States, 30342
Suspended
30
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho, United States, 83706
Suspended
31
Northwestern University
Chicago, Illinois, United States, 60611
Active, Not Recruiting
32
Decatur Memorial Hospital
Decatur, Illinois, United States, 62526
Actively Recruiting
33
Loyola University Medical Center
Maywood, Illinois, United States, 60153
Suspended
34
HSHS Saint Elizabeth's Hospital
O'Fallon, Illinois, United States, 62269
Actively Recruiting
35
Methodist Medical Center of Illinois
Peoria, Illinois, United States, 61636
Actively Recruiting
36
OSF Saint Francis Medical Center
Peoria, Illinois, United States, 61637
Actively Recruiting
37
Carle Cancer Center
Urbana, Illinois, United States, 61801
Actively Recruiting
38
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, United States, 60555
Active, Not Recruiting
39
Community Cancer Center North
Indianapolis, Indiana, United States, 46256
Active, Not Recruiting
40
Iowa Methodist Medical Center
Des Moines, Iowa, United States, 50309
Actively Recruiting
41
Luminis Health Anne Arundel Medical Center
Annapolis, Maryland, United States, 21401
Active, Not Recruiting
42
Walter Reed National Military Medical Center
Bethesda, Maryland, United States, 20889-5600
Actively Recruiting
43
Tufts Medical Center
Boston, Massachusetts, United States, 02111
Actively Recruiting
44
University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
45
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Active, Not Recruiting
46
Regions Hospital
Saint Paul, Minnesota, United States, 55101
Suspended
47
Saint Francis Medical Center
Cape Girardeau, Missouri, United States, 63703
Actively Recruiting
48
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri, United States, 63376
Actively Recruiting
49
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri, United States, 63141
Actively Recruiting
50
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
51
Siteman Cancer Center-South County
St Louis, Missouri, United States, 63129
Actively Recruiting
52
Missouri Baptist Medical Center
St Louis, Missouri, United States, 63131
Actively Recruiting
53
Billings Clinic Cancer Center
Billings, Montana, United States, 59101
Suspended
54
Benefis Sletten Cancer Institute
Great Falls, Montana, United States, 59405
Actively Recruiting
55
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire, United States, 03756
Active, Not Recruiting
56
AtlantiCare Surgery Center
Egg Harbor, New Jersey, United States, 08234
Actively Recruiting
57
State University of New York Upstate Medical University
Syracuse, New York, United States, 13210
Actively Recruiting
58
SUNY Upstate Medical Center-Community Campus
Syracuse, New York, United States, 13215
Suspended
59
Mission Hospital
Asheville, North Carolina, United States, 28801
Active, Not Recruiting
60
Cone Health Cancer Center
Greensboro, North Carolina, United States, 27403
Actively Recruiting
61
East Carolina University
Greenville, North Carolina, United States, 27834
Active, Not Recruiting
62
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
63
Sanford Bismarck Medical Center
Bismarck, North Dakota, United States, 58501
Actively Recruiting
64
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States, 73104
Active, Not Recruiting
65
Legacy Good Samaritan Hospital and Medical Center
Portland, Oregon, United States, 97210
Actively Recruiting
66
Geisinger Medical Center
Danville, Pennsylvania, United States, 17822
Actively Recruiting
67
Fox Chase Cancer Center Buckingham
Furlong, Pennsylvania, United States, 18925
Active, Not Recruiting
68
Fox Chase Cancer Center
Philadelphia, Pennsylvania, United States, 19111
Active, Not Recruiting
69
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania, United States, 18711
Actively Recruiting
70
Self Regional Healthcare
Greenwood, South Carolina, United States, 29646
Active, Not Recruiting
71
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, United States, 84112
Suspended
72
Dartmouth Cancer Center - North
Saint Johnsbury, Vermont, United States, 05819
Active, Not Recruiting
73
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
74
Arthur J E Child Comprehensive Cancer Centre
Calgary, Alberta, Canada, T2N 5G2
Actively Recruiting
75
Cross Cancer Institute
Edmonton, Alberta, Canada, T6G 1Z2
Actively Recruiting
76
BCCA-Vancouver Cancer Centre
Vancouver, British Columbia, Canada, V5Z 4E6
Actively Recruiting
77
QEII Health Sciences Centre/Nova Scotia Health Authority
Halifax, Nova Scotia, Canada, B3H 2Y9
Actively Recruiting
78
Juravinski Cancer Centre at Hamilton Health Sciences
Hamilton, Ontario, Canada, L8V 5C2
Active, Not Recruiting
79
London Regional Cancer Program
London, Ontario, Canada, N6A 4L6
Actively Recruiting
80
University Health Network-Princess Margaret Hospital
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
81
CSSS Champlain-Charles Le Moyne
Greenfield Park, Quebec, Canada, J4V 2H1
Suspended
82
CHUM - Centre Hospitalier de l'Universite de Montreal
Montreal, Quebec, Canada, H2X 3E4
Actively Recruiting
83
The Research Institute of the McGill University Health Centre (MUHC)
Montreal, Quebec, Canada, H3H 2R9
Suspended
84
Jewish General Hospital
Montreal, Quebec, Canada, H3T 1E2
Actively Recruiting
85
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)
Québec, Quebec, Canada, G1R 2J6
Actively Recruiting
86
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
Sherbrooke, Quebec, Canada, J1H 5N4
Suspended
Research Team
C
Chris O'Callaghan
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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