Actively Recruiting
Cognitive Aging in Older Long-term Breast Cancer Survivors
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-05-14
420
Participants Needed
7
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying how thinking and memory abilities change over time in women who have survived breast cancer compared to women of the same age without cancer. The study looks at mental functions like memory, attention, and how information is processed. It aims to understand differences in cognitive function as people age, especially focusing on breast cancer survivors. Participants will complete a one-time, remote cognitive testing session using the CogSuite Neurocognitive Battery, which includes online tests of memory and thinking skills, along with standard neuropsychological measures. Additionally, participants will provide saliva samples by mail to analyze their Apolipoprotein E (APOE) gene status. Both breast cancer survivors and healthy volunteers will undergo this assessment. During the study, participants will answer questions about their demographics and health, and complete cognitive tests remotely. The primary measurement is to examine cognitive effects within 45 days of consenting. Researchers will also measure smoking exposure levels within the same timeframe. The study is observational and involves no treatment; participation is remote and designed to be convenient, with all activities completed once.
CONDITIONS
Brief Title
A Study of Changes in Thinking Related to Aging and Cancer in Breast Cancer Survivors (TRAC)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Identifies as female
- Age between 60 and 80 years
- Has access to a computer and internet
- Score less than 11 on Blessed Orientation-Memory-Concentration Test
- If taking psychoactive medications, dose stable for at least two months prior to enrollment
- Fluent in English and able to understand study conversations
- History of stage 0-3 breast cancer diagnosed between age 50-60 (for breast cancer survivors)
- No evidence of disease (for breast cancer survivors)
- No history of breast cancer (for non-cancer controls)
You will not qualify if you...
- Diagnosis of neurodegenerative disorders affecting cognition (e.g., Alzheimer's, Parkinson's, Multiple Sclerosis, Dementia, Seizure Disorders)
- History of stroke or head injury causing brain lesion or ongoing cognitive difficulties
- Major psychiatric disorders including schizophrenia spectrum, bipolar disorder, substance use disorder, or schizotypal personality disorder
- Visual or hearing impairments that prevent completing assessments
- Use of methotrexate, rituximab, or cyclophosphamide for certain autoimmune diseases
- Participation in conflicting neurocognitive research studies
- History of cancer recurrence (for breast cancer survivors)
- History of other cancers except nonmelanoma skin cancer or first breast cancer (for breast cancer survivors)
- Breast cancer treated only with surgery (for breast cancer survivors)
- History of cancer treatment with radiation, chemotherapy, or hormone therapy (for non-cancer controls)
- Any history of cancer except nonmelanoma skin cancer (for non-cancer controls)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 remote screening and enrollment visit
Duration - Within 45 days of participant consent
Participants complete a one-time remote neurocognitive assessment and provide DNA samples via mailed saliva kits to assess APOE status.
1 remote assessment visit
Duration - Up to study completion
Participants are observed for cognitive changes and smoking exposure levels after the assessment.
No in-person visits; remote follow-up as needed
Trial Site Locations
Total: 7 locations
1
Memorial Sloan Kettering Basking Ridge (All Protocol Activities)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
2
Memorial Sloan Kettering Monmouth (All protocol activities)
Middletown, New Jersey, United States, 07748
Actively Recruiting
3
Memorial Sloan Kettering Bergen (All Protocol Activities)
Montvale, New Jersey, United States, 07645
Actively Recruiting
4
Memorial Sloan Kettering Suffolk - Commack (All Protocol Activities)
Commack, New York, United States, 11725
Actively Recruiting
5
Memorial Sloan Kettering Westchester (All Protocol Activities)
Harrison, New York, United States, 10604
Actively Recruiting
6
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
7
Memorial Sloan Kettering Nassau (All Protocol Activities)
Uniondale, New York, United States, 11553
Actively Recruiting
Research Team
J
James Root, PhD
D
Denise Correa, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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