What is this study trying to find out about breast cancer survivors?

This study aims to understand how thinking and memory skills change over time in older women who survived breast cancer compared to those without cancer. Researchers are comparing cognitive test results between these groups to learn about differences in mental function related to aging and cancer. The study is led by Memorial Sloan Kettering Cancer Center.

Who may be eligible for this breast cancer survivor clinical trial?

Women aged 60 to 80 who identify as female and either are breast cancer survivors diagnosed between ages 50 and 60 with no current disease, or have no history of breast cancer, may be eligible. Participants must be fluent in English and have access to a computer and internet. Please review eligibility criteria for more details.

Is there any cost to participate in this breast cancer survivor clinical trial?

Study-related care, including all assessments and trial activities, is provided at no cost. Personal travel expenses may vary and are not guaranteed to be covered. Participants can complete study activities remotely to reduce travel needs.

Actively Recruiting

Age: 60Years - 80Years

FEMALE

Healthy Volunteers

ID06334354

Study of Cognitive Changes and Aging in Older Female Breast Cancer Survivors Compared to Healthy Volunteers

Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-05-14

420

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

Researchers are studying how thinking and memory abilities change over time in women who have survived breast cancer compared to women of the same age without cancer. The study looks at mental functions like memory, attention, and how information is processed. It aims to understand differences in cognitive function as people age, especially focusing on breast cancer survivors. Participants will complete a one-time, remote cognitive testing session using the CogSuite Neurocognitive Battery, which includes online tests of memory and thinking skills, along with standard neuropsychological measures. Additionally, participants will provide saliva samples by mail to analyze their Apolipoprotein E APOE gene status. Both breast cancer survivors and healthy volunteers will undergo this assessment. During the study, participants will answer questions about their demographics and health, and complete cognitive tests remotely. The primary measurement is to examine cognitive effects within 45 days of consenting. Researchers will also measure smoking exposure levels within the same timeframe. The study is observational and involves no treatment participation is remote and designed to be convenient, with all activities completed once.

CONDITIONS

Brief Title

A Study of Changes in Thinking Related to Aging and Cancer in Breast Cancer Survivors (TRAC)

Who Can Participate

Age: 60Years - 80Years

FEMALE

Healthy Volunteers

Eligibility Criteria

You may qualify if you...

Identifies as female
Age between 60 and 80 years
Has access to a computer and internet
Score less than 11 on Blessed Orientation-Memory-Concentration Test
If taking psychoactive medications, dose stable for at least two months prior to enrollment
Fluent in English and able to understand study conversations
History of stage 0-3 breast cancer diagnosed between age 50-60 (for breast cancer survivors)
No evidence of disease (for breast cancer survivors)
No history of breast cancer (for non-cancer controls)

You will not qualify if you...

Diagnosis of neurodegenerative disorders affecting cognition (e.g., Alzheimer's, Parkinson's, Multiple Sclerosis, Dementia, Seizure Disorders)
History of stroke or head injury causing brain lesion or ongoing cognitive difficulties
Major psychiatric disorders including schizophrenia spectrum, bipolar disorder, substance use disorder, or schizotypal personality disorder
Visual or hearing impairments that prevent completing assessments
Use of methotrexate, rituximab, or cyclophosphamide for certain autoimmune diseases
Participation in conflicting neurocognitive research studies
History of cancer recurrence (for breast cancer survivors)
History of other cancers except nonmelanoma skin cancer or first breast cancer (for breast cancer survivors)
Breast cancer treated only with surgery (for breast cancer survivors)
History of cancer treatment with radiation, chemotherapy, or hormone therapy (for non-cancer controls)
Any history of cancer except nonmelanoma skin cancer (for non-cancer controls)

Research Team

James Root, PhD

Denise Correa, PhD

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Study of Cognitive Changes and Aging in Older Female Breast Cancer Survivors Compared to Healthy Volunteers

On this page

AI-Summary

What this Trial Is About

Brief Title

Who Can Participate

Eligibility Criteria

Research Team

Not the Right Trial for You?

On this page

Who Can Participate

Eligibility Criteria