Actively Recruiting
A Study of Changes in Thinking Related to Aging and Cancer in Breast Cancer Survivors (TRAC)
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-05-14
420
Participants Needed
7
Research Sites
224 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to look at how differences in cognitive (mental) function develop over time in breast cancer survivors compared to volunteers without a history of cancer (healthy volunteers). Both cancer survivors and healthy volunteers (who are the same age as the cancer survivors) will participate in this study so the researchers can compare the results of neurocognitive testing (which looks at memory, attention, and information processing) on each group of participants.
CONDITIONS
Official Title
A Study of Changes in Thinking Related to Aging and Cancer in Breast Cancer Survivors (TRAC)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Identifies as female by medical record or self-report
- Age between 60 and 80 years
- Access to a computer and internet connectivity
- Score less than 11 on the Blessed Orientation-Memory-Concentration Test (BOMC)
- If taking psychoactive medications, dose must have been stable for at least two months prior to enrollment
- Fluent in English, speaking well or very well with good comprehension
- For breast cancer survivors: history of stage 0-3 breast cancer diagnosed between ages 50 and 60
- For breast cancer survivors: no evidence of disease
- For non-cancer controls: no history of breast cancer
- English fluency verified by answering specific language questions
You will not qualify if you...
- Diagnosis of neurodegenerative disorder affecting cognition (e.g., Alzheimer's, Parkinson's, Multiple Sclerosis, Dementia, Seizure Disorders)
- History of stroke or head injury causing structural brain lesions, ongoing cognitive difficulties, or need for cognitive rehabilitation
- Diagnosis of major Axis I psychiatric disorders including Schizophrenia Spectrum Disorder, substance use disorder, Bipolar Disorder, or Schizotypal personality disorder
- Visual or hearing impairments that prevent completing assessments
- Use of methotrexate, rituximab, or cyclophosphamide for certain autoimmune diseases
- Participation in conflicting neurocognitive research studies
- For breast cancer survivors: history of cancer recurrence
- For breast cancer survivors: history of other cancers except nonmelanoma skin cancer or first breast cancer; secondary breast cancer excluded
- For breast cancer survivors: breast cancer treated only with surgery
- For non-cancer controls: history of treatments including radiation, chemotherapy, Tamoxifen, or Aromatase-inhibitors
- For non-cancer controls: any history of cancer except nonmelanoma skin cancer
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
Memorial Sloan Kettering Basking Ridge (All Protocol Activities)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
2
Memorial Sloan Kettering Monmouth (All protocol activities)
Middletown, New Jersey, United States, 07748
Actively Recruiting
3
Memorial Sloan Kettering Bergen (All Protocol Activities)
Montvale, New Jersey, United States, 07645
Actively Recruiting
4
Memorial Sloan Kettering Suffolk - Commack (All Protocol Activities)
Commack, New York, United States, 11725
Actively Recruiting
5
Memorial Sloan Kettering Westchester (All Protocol Activities)
Harrison, New York, United States, 10604
Actively Recruiting
6
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
7
Memorial Sloan Kettering Nassau (All Protocol Activities)
Uniondale, New York, United States, 11553
Actively Recruiting
Research Team
J
James Root, PhD
CONTACT
D
Denise Correa, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here