Actively Recruiting
A Study on the Correlation Between Oral Health and Delirium in Surgical Inpatients
Led by Xinhua Hospital, Shanghai Jiao Tong University School of Medicine · Updated on 2025-05-13
550
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Delirium is a clinical syndrome marked by sudden attention problems, changes in consciousness, and fluctuating thinking abilities. It often occurs in hospitalized elderly patients after surgery, especially in intensive care units, leading to worse recovery, higher death rates, longer hospital stays, and increased healthcare costs. This research investigates how oral health, particularly a condition called oral frailty, may be linked to postoperative delirium and cognitive decline in surgical patients. The study observes surgical patients who have or do not have oral frailty before elective cardiac or thoracic surgery requiring endotracheal intubation. Oral frailty is assessed using a specific scale before surgery. Participants are grouped based on the presence or absence of oral frailty to explore its relationship with delirium and other postoperative outcomes. Participants will be monitored for delirium within one week after surgery. Other evaluations include swallowing ability, appetite, and blood protein levels measured within 48 hours after removing the breathing tube, as well as routine postoperative blood tests during the first week. The study aims to understand connections between oral health and cognitive changes after surgery, potentially guiding future prevention strategies. Participation lasts throughout the perioperative and early postoperative period.
CONDITIONS
Brief Title
A Study on the Correlation Between Oral Health and Delirium in Surgical Inpatients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 years or older scheduled for elective cardiac or thoracic surgery requiring endotracheal intubation
- Patients without consciousness impairment who can cooperate with study procedures
- Patients or legal guardians who have been informed about the study and signed consent forms
You will not qualify if you...
- Patients with pre-existing oral conditions such as dry mouth or oral mucosal lesions prior to mechanical ventilation
- Patients with a history of radiotherapy, chemotherapy, or corticosteroid use before surgery
- Patients who experience death during surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Short period before surgery
Participants undergo assessment of oral frailty using a scale prior to surgery.
1 visit (in-person)
Duration - Up to 1 week postoperatively
Participants undergo elective cardiac or thoracic surgery requiring endotracheal intubation and immediate postoperative monitoring.
Assessments within 48 hours after removal of the endotracheal tube and routine postoperative evaluations within the first week
Duration - Within one week postoperatively
Participants are observed for development of delirium and other postoperative outcomes during the first week after surgery.
Follow-up assessments during the first postoperative week
Trial Site Locations
Total: 1 location
1
Shanghai Xinhua hospital
Shanghai, Shanghai Municipality, China, 200092
Actively Recruiting
Research Team
A
Aimin Shao, master
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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