Actively Recruiting
Study of the Disease Process of Lymphangioleiomyomatosis
Led by National Heart, Lung, and Blood Institute (NHLBI) · Updated on 2026-05-07
2000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Pulmonary lymphangioleiomyomatosis (LAM) is a destructive lung disease typically affecting women of childbearing age. Currently, there is no effective therapy for the disease and the prognosis is poor. This study is designed to determine the disease processes involved at the level of cells and molecules, in order to develop more effective therapy. Researchers intend to identify the proteins and genes that contribute to the process of lung destruction in affected individuals. ...
CONDITIONS
Official Title
Study of the Disease Process of Lymphangioleiomyomatosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Lung biopsy showing lymphangioleiomyomatosis (LAM) or chest x-ray/CT scan consistent with LAM
- Patients with tuberous sclerosis complex (TSC) and pulmonary LAM
- Normal non-smokers with no systemic or lung disease and no smoking for 1 year or more (control group)
- Normal smokers with no systemic or lung disease, smoking for 1 year or more, normal chest x-ray and lung function (control group)
- Pregnant or nursing women can be included but will not undergo higher-risk procedures during pregnancy or nursing
You will not qualify if you...
- Age under 16 years
- Advanced pulmonary or systemic illness posing significant risk during study procedures
- Use of continuous oxygen for formal exercise or stress echocardiogram studies (exercise test may still be performed)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
T
Tatyana A Worthy, R.N.
CONTACT
J
Joel Moss, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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