Study of Beta-Hydroxy-Beta-Methylbutyrate HMB and 2-Hydroxybenzylamine 2-HOBA Supplements Alone or Together to Improve Muscle Strength and Cognitive Health in Adults 65 and Older

What this Trial Is About

This research aims to study the effects of two dietary supplements, beta-hydroxy-beta-methylbutyrate HMB and 2-hydroxybenzylamine 2-HOBA, either alone or combined, on muscle strength, cognitive function, and overall health in adults aged 65 and older. These supplements, considered nutraceuticals, may help extend the period of good health by targeting aging processes and protecting against chronic diseases. The study is led by McGill University Health Centre and explores the potential of these natural compounds in aging populations. Participants will be randomly assigned to one of four groups HMB alone, 2-HOBA alone, a combination of both supplements, or a placebo group. Each treatment is given as tablets taken twice daily for 90 days, with specific doses for each supplement. The placebo group receives tablets matching the active supplements in appearance but without the active ingredients. The study uses a quadruple-blind design to fairly assess the effects of these supplements on health. During the 90-day study, participants will attend scheduled visits where researchers will evaluate muscle strength, physical function, cardiorespiratory fitness, immune function, cognitive function using specific cognitive tools, and inflammatory markers. Blood samples will be collected to measure metabolism, inflammation, and oxidative stress markers. Safety and side effects will be monitored throughout. The main outcome is the change in muscle mass after 12 weeks of supplementation. Participants are followed closely to assess overall health benefits and any risks associated with the supplements.

This Study Investigates β-hydroxy-β-methylbutyrate (HMB) and 2-hydroxybenzylamine (2-HOBA), When Administered Either Individually or in Combination Contributes to an Increased Quality of Health, Specifically Improving Muscular Strength and Cognitive Functioning in Adults Over the Age of 65.