Actively Recruiting
A Within Patient, Pilot Randomized Controlled Study of Plurogel4 Compared to Standard Topical Dressing in Burn Injuries
Led by University of Manitoba · Updated on 2026-05-14
20
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Burn injuries can cause long-lasting physical and mental challenges due to scarring and painful dressings. The usual treatment involves antibiotic topical dressings while waiting to determine the burn depth, followed by surgery for deeper burns. Assessing burn depth is complex and can take weeks, with surgical removal of tissue often removing some healthy tissue. New methods like hydro-dissection devices and enzymatic debridement have been explored but lack definitive proof of benefit and may sometimes cause harm. This trial is studying PluroGel®, a gel that helps clean burn wounds by loosening and removing dead tissue while keeping the wound moist. Participants will receive either the standard antibiotic ointment and gauze dressing or PluroGel® plus the standard dressing with moist gauze. Dressings are applied every Monday, Wednesday, and Friday, with moist gauze kept wet twice daily in the PluroGel® group. This is a randomized, double-blind study comparing these two approaches. Participants will be monitored to see how much of the burn heals within 14 days and whether surgery is needed during this time. The study includes regular dressing changes and wound evaluations. The trial aims to gather evidence on the healing effects of PluroGel® compared to standard care over this two-week period. Participation lasts at least 14 days, with close follow-up to assess wound healing and treatment safety.
CONDITIONS
Brief Title
A Study of Plurogel® Compared to Standard Topical Dressing in Burn Injuries
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Persons with bilateral limb partial thickness burn injuries of similar depth requiring admission
You will not qualify if you...
- Total body surface area (TBSA) of burn >30%
- Burn depth full thickness or deeper on initial assessment
- Prior excision at another healthcare centre
- Patients with pre-existing malnutrition
- Electrical, chemical or other unusual burn etiologies
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 14 days
Participants receive either the standard topical antibiotic dressing or PluroGel® with standard dressing on burn injuries. Dressings are applied every Monday, Wednesday, and Friday, with moistened gauze kept moist twice daily for the PluroGel® group.
3 visits per week for up to 2 weeks
Trial Site Locations
Total: 1 location
1
University of Manitoba
Winnipeg, Manitoba, Canada, R3A 1R9
Actively Recruiting
Research Team
J
Justin Gawaziuk
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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