Actively Recruiting
ANCABio - Study of Tumour Microenvironment and Biopsies to Predict Treatment Response and Outcome in Anal Cancer
Led by Sahlgrenska University Hospital · Updated on 2025-03-18
400
Participants Needed
2
Research Sites
104 weeks
Total Duration
On this page
Sponsors
S
Sahlgrenska University Hospital
Lead Sponsor
G
Göteborg University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating the tumor biology related to treatment response in patients with anal cancer. They aim to understand the tumor microenvironment, the location and interactions between tumor and immune cells, and the gene and protein expression in tumor and surrounding tissues. This study focuses on adult patients treated or diagnosed at Sahlgrenska University Hospital. Participants who are newly diagnosed or have a suspected recurrence will be invited to provide biopsies and blood samples during diagnostic exams performed under anesthesia. Additional biopsies may be collected during follow-up exams, surgery, or further anesthesia examinations after treatment. If biopsies cannot be taken before treatment, blood samples will still be collected. During the study, patients will undergo biopsies and blood sample collection at various time points including diagnosis, recurrence, and follow-up. Researchers will monitor the tumor microenvironment and circulating tumor DNA from 2024 to 2029. The study will gather detailed biological information to help predict treatment response and outcomes in anal cancer. Participation involves regular medical assessments and sample collections over several years.
CONDITIONS
Brief Title
A Study Regarding Tissue Response During and After Treatment for Anal Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Newly diagnosed or recurrent anal cancer
You will not qualify if you...
- No diagnosis of anal cancer
- Contraindication to biopsies and blood samples
AI-Screening
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Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - At diagnosis or suspected recurrence
Participants undergo diagnostic examinations including biopsies and blood samples under anaesthesia to assess their condition before treatment.
1 visit (in-person)
Duration - Up to 5 years
Participants have biopsies and blood samples taken during follow-up exams, surgery if scheduled, or examinations under anaesthesia after treatment ends to monitor tissue response and outcomes.
Periodic visits depending on treatment and follow-up schedule
Trial Site Locations
Total: 2 locations
1
Dept. of Surgery, Sahlgrenska University Hospital/Ostra
Gothenburg, Sweden, SE 416 85
Actively Recruiting
2
Sahlgrenska University Hospital
Gothenburg, Sweden
Actively Recruiting
Research Team
E
Eva Angenete PI, Professor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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