Study of Tumor Environment and Biopsy Analysis in Adults With Anal Cancer to Predict Treatment Response and Outcomes

What this Trial Is About

Researchers are investigating the tumor biology related to treatment response in patients with anal cancer. They aim to understand the tumor microenvironment, the location and interactions between tumor and immune cells, and the gene and protein expression in tumor and surrounding tissues. This study focuses on adult patients treated or diagnosed at Sahlgrenska University Hospital. Participants who are newly diagnosed or have a suspected recurrence will be invited to provide biopsies and blood samples during diagnostic exams performed under anesthesia. Additional biopsies may be collected during follow-up exams, surgery, or further anesthesia examinations after treatment. If biopsies cannot be taken before treatment, blood samples will still be collected. During the study, patients will undergo biopsies and blood sample collection at various time points including diagnosis, recurrence, and follow-up. Researchers will monitor the tumor microenvironment and circulating tumor DNA from 2024 to 2029. The study will gather detailed biological information to help predict treatment response and outcomes in anal cancer. Participation involves regular medical assessments and sample collections over several years.

A Study Regarding Tissue Response During and After Treatment for Anal Cancer