Actively Recruiting
Shedding of Syncytiotrophoblast-derived Extracellular Vesicles is Increased in Placenta Previa and Accreta Spectrum: a Case-control Study
Led by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Updated on 2025-03-10
70
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying pregnant women to measure levels of syncytiotrophoblast-derived extracellular vesicles (STBEVs) in the blood. The study focuses on women diagnosed with placenta previa and placenta accreta spectrum compared to those with normal placentation. It aims to better understand these conditions by analyzing the proteins, genes, and transcripts carried by these vesicles. Participants include pregnant women diagnosed with abnormal placentation conditions such as placenta previa and accreta spectrum, as well as healthy pregnant women. The study involves collecting blood samples during the third trimester (around nine months of pregnancy) to quantify circulating extracellular vesicles and perform proteomics analysis. During the study, participants will provide blood samples for laboratory tests that measure the concentration and protein makeup of extracellular vesicles. Researchers will track these markers to compare affected women with healthy controls. The study includes women aged 18 and older and monitors outcomes during the late stage of pregnancy to gather detailed biological data relevant to placental health.
CONDITIONS
Brief Title
Syncytiotrophoblast-derived Extracellular Vesicles in Placenta Previa and Accreta Spectrum
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnant women diagnosed with placenta previa and accreta spectrum
- Healthy pregnant women
- Women aged 18 years or older
You will not qualify if you...
- Under 18 years of age
- Twin pregnancies
- Chronic infections
- Cancers
- Unable to give written consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 9 months (three trimesters of pregnancy)
Participants have blood samples collected to measure circulating extracellular vesicles during pregnancy.
1 to 3 visits during pregnancy depending on trimester
Trial Site Locations
Total: 1 location
1
Fondazione Policlinico Universitario A.Gemelli IRCSS
Roma, Italy, 00168
Actively Recruiting
Research Team
C
Chiara Tersigni
M
Marianna Onori
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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