Actively Recruiting

Age: 18Years - 65Years
All Genders
ID07312409

Does Taurine Supplementation Improve Vascular Function and Orthostatic Responses in Long COVID?

Led by York University · Updated on 2026-06-05

30

Participants Needed

1

Research Sites

26 weeks

Total Duration

On this page

Sponsors

Y

York University

Lead Sponsor

C

Canadian Institutes of Health Research (CIHR)

Collaborating Sponsor

AI-Summary

What this Trial Is About

This research aims to evaluate whether 12 weeks of taurine supplementation can improve vascular function and cardiovascular responses to upright posture in people with Long COVID. Long COVID is defined as new or continuing symptoms lasting at least two months, starting three months after COVID-19 infection, and it is linked to vascular dysfunction and taurine deficiency. The study will focus on measuring vascular health and orthostatic tolerance, which relates to symptoms like lightheadedness when standing. Participants will either be taking taurine supplements for 12 weeks or not taking them, forming two groups for comparison. Vascular function will be assessed using devices like EndoPAT and Duplex ultrasound, while orthostatic responses will be measured during a 5-minute head-up tilt test. Heart rate variability will be recorded both in the lab and at home weekly using a heart rate monitor. The study involves two visits at baseline and after 12 weeks, with at-home monitoring in between. During the study, participants will undergo detailed assessments including blood flow, heart rate, blood pressure, and brain blood flow measurements. Questionnaires will track symptoms and autonomic function. Researchers will analyze changes before and after 12 weeks to understand the effects of taurine supplementation. The total participation time includes two one-hour lab visits and weekly home data collection over 12 weeks.

CONDITIONS

Brief Title

Does Taurine Supplementation Improve Vascular Function and Orthostatic Responses in Long COVID?

Who Can Participate

Age: 18Years - 65Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Participants will have had symptoms of Long COVID post-infection for at least 3 months
  • Aged 18 to 65 years
  • Ability to undergo tilt table testing for 5 minutes
  • Ability to travel to York University for study visits
  • Ability to speak English or provide a translator
Not Eligible

You will not qualify if you...

  • Inability to undergo tilt table testing for 5 minutes
  • Inability to transport selves to York University from their homes
  • Inability to speak English, or provide a translator
  • Blood clotting disorders

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Observational Period

Duration - 12 weeks

Participants are observed to compare those who are taking 12 weeks of taurine supplementation with those who are not taking taurine.

2 visits (baseline and after 12 weeks, in-person)

Trial Site Locations

Total: 1 location

1

York University

Toronto, Ontario, Canada, M3J1P3

Actively Recruiting

Loading map...

Research Team

H

Heather Edgell, PhD

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

Similar Trials

Frequently Asked Questions

Have more questions? Get in touch with our team for quick support

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here

Published Research Related To This Trial

Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology.

https://pubmed.ncbi.nlm.nih.gov/8598068

Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force.

Mary C Corretti, Todd J Anderson, Emelia J Benjamin...

https://pubmed.ncbi.nlm.nih.gov/11788217

Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study.

Qianqian Sun, Bin Wang, Yingsha Li...

https://pubmed.ncbi.nlm.nih.gov/26781281

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.

Markus Hoffmann, Hannah Kleine-Weber, Simon Schroeder...

https://pubmed.ncbi.nlm.nih.gov/32142651