Actively Recruiting

Age: 18Years +
All Genders
ID06466941

Impact of Patient Phenotypic Features on the Experience and Effectiveness of Regional Anesthesia and Postoperative Pain

Led by Brigham and Women's Hospital · Updated on 2026-05-22

1000

Participants Needed

1

Research Sites

52 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are investigating how regional anesthesia, which involves numbing medications like epidurals or nerve blocks, affects pain in patients undergoing various types of surgery, including thoracic, open abdominal, orthopedic, and spine surgeries. They aim to understand how different psychological factors such as anxiety, sleep issues, and concerns about pain influence the effectiveness of regional anesthesia. The study also explores how these factors impact opioid use after surgery and the development of chronic postsurgical pain. Participants in this observational study include patients who have surgery and may receive regional anesthesia or not. Some patients may also have an acute pain consultation before, during, or after surgery. The study does not assign treatments but observes patients based on whether they receive these procedures. The research uses surveys and interviews to capture patients' psychological profiles and their experiences with pain and anesthesia. During the study, participants will provide information through psychosocial surveys and recorded interviews. Researchers will collect data on pain scores over the first 24 hours after surgery, daily pain levels for a week, and opioid use during this time. The primary measurement is the highest pain score within the first 24 hours post-surgery. The study is designed to better understand how patient characteristics relate to pain management and opioid use after surgery.

CONDITIONS

Brief Title

Understanding the Acute Pain Phenotype in Patients Undergoing Surgery

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 years or older
  • Able to speak English
  • Scheduled for surgery or procedure requiring postoperative hospital admission
  • Willing to complete psychosocial surveys and/or recorded interviews
Not Eligible

You will not qualify if you...

  • Cognitive dysfunction that prevents communication

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Surgery

Duration - Day of surgery

Participants undergo thoracic, open abdominal, orthopedic, or spine surgery with or without regional anesthesia or acute pain consultation as part of their surgical care.

1 visit (in-person)

Post-operative Follow-up

Duration - 7 days

Participants have daily assessments of pain scores and opioid consumption for up to 7 days after surgery.

Daily visits or assessments for up to 7 days

Trial Site Locations

Total: 1 location

1

Brigham and Women's Hospital

Boston, Massachusetts, United States, 02115

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Research Team

Y

Yun-Yun K Chen, MD

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

3

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Published Research Related To This Trial

The role of regional anaesthesia and multimodal analgesia in the prevention of chronic postoperative pain: a narrative review.

Y-Y K Chen, K A Boden, K L Schreiber

https://pubmed.ncbi.nlm.nih.gov/33426669

Prediction of Persistent Pain Severity and Impact 12 Months After Breast Surgery Using Comprehensive Preoperative Assessment of Biopsychosocial Pain Modulators.

Kristin L Schreiber, Nantthansorn Zinboonyahgoon, K Mikayla Flowers...

https://pubmed.ncbi.nlm.nih.gov/33452600