Using Sublingual Videomicroscopy to Predict Bleeding Risk in Von Willebrand Disease and Other Bleeding Disorders

What this Trial Is About

Researchers are investigating whether sublingual videomicroscopy, a non-invasive and sensitive technique that analyzes capillary density under the tongue, can predict bleeding risk in patients with von Willebrand disease and other congenital bleeding disorders such as Glanzmann Thrombasthenia and moderate to severe Hemophilia A, including women carrying the hemophilia gene. This study addresses the current lack of non-invasive tests to identify patients at high risk of bleeding from angiodysplasias. Participants will undergo sublingual videomicroscopy to measure capillary density, alongside blood sample collection at the start and after 36 months. The study includes two groups patients with hemorrhagic diseases and a control group. The primary focus is to assess the predictive value of sublingual capillary density for significant bleeding events over three years. During the study, participants will have baseline and three-year evaluations including capillary density, qualitative capillary abnormalities, bleeding scores using the ISTH-BAT tool, and plasma levels of proangiogenic markers such as galectine and VEGF. The main outcome is the correlation between capillary density and bleeding events within three years. The study spans three years, monitoring participants bleeding risk and related biological markers over this period.

Videomicroscopy for the Prediction of Bleeding in Constitutional Haemorrhagic Diseases