Effects of hormone replacement therapy and antioxidant vitamin supplements on coronary atherosclerosis in postmenopausal women: a randomized controlled trial.
David D Waters, Edwin L Alderman, Judith Hsia...
https://pubmed.ncbi.nlm.nih.gov/12435256Completed
Phase 3
Age: 38Years - 86Years
FEMALE
ID00000555
Led by National Heart, Lung, and Blood Institute (NHLBI) · Updated on 2016-07-12
N/A
Participants Needed
N/A
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
To assess whether hormonal replacement therapy and/or antioxidant treatment would stabilize or inhibit progression, and induce regression of coronary plaques. The mechanisms by which these treatments modified atherosclerosis in women were also explored.
CONDITIONS
Official Title
Women's Angiographic Vitamin and Estrogen Trial (WAVE)
Who Can Participate
Age: 38Years - 86Years
FEMALE
Eligibility Criteria
You may qualify if you...
Postmenopausal women, up to age 86, with angiographically documented coronary artery disease of at least 15 percent, but no more than 75 percent occlusion.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Site Locations not provided
Location information for this trial is currently unavailable.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
PREVENTION
Number of Arms
0
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Published Research Related To This Trial
Women's angiographic vitamin and estrogen trial: design and methods.
Judith Hsia, Edwin L Alderman, Joel I Verter...
https://pubmed.ncbi.nlm.nih.gov/12505248Metabolic syndrome and coronary angiographic disease progression: the Women's Angiographic Vitamin & Estrogen trial.
Judith Hsia, Vera Bittner, Mark Tripputi...
https://pubmed.ncbi.nlm.nih.gov/12947360Postmenopausal hormone therapy is associated with atherosclerosis progression in women with abnormal glucose tolerance.
Barbara V Howard, Judith Hsia, Pamela Ouyang...
https://pubmed.ncbi.nlm.nih.gov/15226212The effect of vitamin therapy on the progression of coronary artery atherosclerosis varies by haptoglobin type in postmenopausal women.
Andrew P Levy, Paula Friedenberg, Rachel Lotan...
https://pubmed.ncbi.nlm.nih.gov/15047650Remnant-like lipoproteins, hormone therapy, and angiographic and clinical outcomes: the Women's Angiographic Vitamin & Estrogen Trial.
Vera Bittner, Mark Tripputi, Judith Hsia...
https://pubmed.ncbi.nlm.nih.gov/15308999Hormone therapy and antioxidant vitamins do not improve endothelial vasodilator function in postmenopausal women with established coronary artery disease: a substudy of the Women's Angiographic Vitamin and Estrogen (WAVE) trial.
Mark Kelemen, Dhananjay Vaidya, David D Waters...
https://pubmed.ncbi.nlm.nih.gov/15721027Usefulness of serum endothelin levels in predicting death and myocardial infarction but not coronary progression in postmenopausal women with coronary disease (from the Women's Angiographic Vitamin and Estrogen [WAVE] study).
Bernice Ruo, Mark T Tripputi, Priscilla Y Hsue...
https://pubmed.ncbi.nlm.nih.gov/16054453